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The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Lund Univ, Diabet Ctr, Malmo, Sweden..
Lund Univ, Diabet Ctr, Malmo, Sweden..
Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway..
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 6, article id e0179911Article in journal (Refereed) Published
Abstract [en]

To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Human pancreatic specimens were obtained from a unique cohort of individuals with recent onset or long standing type 1 diabetes. Density of parasympathetic axons was assessed by immunofluorescence and morphometry. Our main finding was a reduced density of parasympathetic axons in the exocrine, but not endocrine compartment of the pancreas in individuals with recent onset type 1 diabetes. The reduced density of parasympathetic axons in the exocrine compartment could have functional implications, e.g. be related to the exocrine insufficiency reported in type 1 diabetes patients. Further studies are needed to understand whether reduced parasympathetic innervation is a cause or consequence of type 1 diabetes.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2017. Vol. 12, no 6, article id e0179911
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-330731DOI: 10.1371/journal.pone.0179911ISI: 000404043100049PubMedID: 28628651OAI: oai:DiVA.org:uu-330731DiVA, id: diva2:1148197
Funder
Novo NordiskEU, FP7, Seventh Framework Programme, 261441 PEVNETSwedish Child Diabetes FoundationSwedish Research Council, 65X-12219-15-6, K2015-54X-12219-19-4, 2008-4216, 521-2012-2119Swedish Diabetes AssociationMagnus Bergvall Foundation
Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2018-05-02Bibliographically approved
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