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Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia
Sachs Children & Youth Hosp, Sodersjukhuset, Dept Pediat, S-11883 Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden..
Sachs Children & Youth Hosp, Sodersjukhuset, Dept Pediat, S-11883 Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
Sachs Children & Youth Hosp, Sodersjukhuset, Dept Pediat, S-11883 Stockholm, Sweden.;Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden..
Sachs Children & Youth Hosp, Sodersjukhuset, Dept Pediat, S-11883 Stockholm, Sweden.;Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden..
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2017 (English)In: BMC Pulmonary Medicine, ISSN 1471-2466, E-ISSN 1471-2466, Vol. 17, article id 97Article in journal (Refereed) Published
Abstract [en]

Background: Bronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age.

Methods: Fifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13-17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry. Comparison with lung function data from school age (6-8 years of age) was also performed.

Results: Adolescents with a history of BPD had lower forced expiratory volume in 1 s (FEV1) compared to those without BPD (-0.61 vs.-0.02 z-scores, P < 0.05), with lower FEV1 values significantly associated with BPD severity (P for trend 0.002). Subjects with severe BPD had higher frequency dependence of resistance, R5-20, (P < 0.001 vs. non-BPD subjects) which is an IOS indicator of peripheral airway involvement. Between school age and adolescence, FEV1/FVC z-scores decreased in all groups and particularly in the severe BPD group (from -1.68 z-scores at 6-8 years to -2.74 z-scores at 13-17 years, p < 0.05 compared to the non-BPD group).

Conclusions: Our results of spirometry and IOS measures in the BPD groups compared to the non-BPD group suggest airway obstruction including involvement of peripheral airways. The longitudinal result of a decrease in FEV1/FVC in the group with severe BPD might implicate a route towards chronic airway obstruction in adulthood.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2017. Vol. 17, article id 97
Keyword [en]
Adolescents, Bronchopulmonary dysplasia, Lung function tests, Oscillometry, Spirometry, Ergospirometry
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-330717DOI: 10.1186/s12890-017-0441-3ISI: 000404911700001PubMedID: 28666441OAI: oai:DiVA.org:uu-330717DiVA, id: diva2:1148013
Funder
Swedish Heart Lung FoundationSwedish Research CouncilSwedish Asthma and Allergy AssociationStockholm County Council
Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2017-11-29Bibliographically approved

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