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Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
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2017 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 6, article id e2642Article in journal (Refereed) Published
Abstract [en]

Probabilistic reward learning is characterised by individual differences that become acute in aging. This may be due to age-related dopamine (DA) decline affecting neural processing in striatum, prefrontal cortex, or both. We examined this by administering a probabilistic reward learning task to younger and older adults, and combining computational modelling of behaviour, fMRI and PET measurements of DA D1 availability. We found that anticipatory value signals in ventromedial prefrontal cortex (vmPFC) were attenuated in older adults. The strength of this signal predicted performance beyond age and was modulated by D1 availability in nucleus accumbens. These results uncover that a value-anticipation mechanism in vmPFC declines in aging, and that this mechanism is associated with DA D1 receptor availability.

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ELIFE SCIENCES PUBLICATIONS LTD , 2017. Vol. 6, article id e2642
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Neurosciences
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URN: urn:nbn:se:umu:diva-140043DOI: 10.7554/eLife.26424ISI: 000410119300001PubMedID: 28870286OAI: oai:DiVA.org:umu-140043DiVA, id: diva2:1147943
Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2018-01-13Bibliographically approved

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Axelsson, JanRiklund, KatrineNyberg, Lars
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