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Rapid diagnosis of acute norovirus-associated gastroenteritis: evaluation of the Xpert Norovirus assay and its implementation as a 24/7 service in three hospitals in Jonkoping County, Sweden
Regional Jönköping County, Sweden.
Regional Jönköping County, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Regional Jonköping County, Sweden.
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2017 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 36, no 10, p. 1867-1871Article in journal (Refereed) Published
Abstract [en]

Noroviruses are a leading cause of epidemic and sporadic cases of acute gastroenteritis worldwide. The rapid diagnosis of norovirus infection is important for prompt infection control measures and may reduce the need for additional diagnostic testing. Here we evaluated the performance of the rapid Xpert Norovirus assay, and assessed the turn-around time (TAT) before and after the implementation of the analysis as a 24/7 service at all the three hospitals in Jonkoping County, Sweden. We describe the implementation process which was performed in two steps during 2014. A total number of 276 clinical samples (stool and vomitus) from patients with symptoms of acute gastroenteritis were included in 2014-2015. The samples were analysed with the Xpert Norovirus assay and the already existing routine method: an in-house reverse transcription real-time PCR. Samples showing discrepant results with the two assays were further analysed by a third PCR method. The Xpert Norovirus assay performed well with a sensitivity of 100% and a specificity of 93% compared to the gold standard (defined as the result obtained by at least two of the three PCR methods). The median TAT decreased from 22 hours in 2013 to 2.4 hours in 2015 (p amp;lt; 0.001). We conclude that the performance of the Xpert Norovirus assay was excellent, and that the implementation of the analysis as a 24/7 service at all three hospitals in the county has greatly reduced the time to diagnosis which is beneficial for both patients and healthcare providers.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 36, no 10, p. 1867-1871
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-141706DOI: 10.1007/s10096-017-3005-9ISI: 000410836300020PubMedID: 28540537OAI: oai:DiVA.org:liu-141706DiVA, id: diva2:1147331
Note

Funding Agencies|Laboratory of Clinical Microbiology, Laboratory Medicine, Region Jonkoping County, Sweden

Available from: 2017-10-05 Created: 2017-10-05 Last updated: 2017-10-24

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