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Future complications of chronic hepatitis C in a low-risk area: projections from the hepatitis c study in Northern Norway
UiT Arctic University of Norway, Norway; University Hospital North Norway, Norway.
Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
UiT Arctic University of Norway, Norway; University Hospital North Norway, Norway.
UiT Arctic University of Norway, Norway.
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2017 (English)In: BMC Infectious Diseases, ISSN 1471-2334, E-ISSN 1471-2334, Vol. 17, article id 624Article in journal (Refereed) Published
Abstract [en]

Background: Hepatitis C (HCV) infection causes an asymptomatic chronic hepatitis in most affected individuals, which often remains undetected until cirrhosis and cirrhosis-related complications occur. Screening of high-risk subjects in Northern Norway has revealed a relatively low prevalence in the general population (0.24%). Despite this, late complications of HCV infection are increasing. Our object was to estimate the future prevalence and complications of chronic HCV infection in the period 2013-2050 in a low-risk area. Methods: We have entered available data into a prognostic Markov model to project future complications to HCV infection. Results: The model extrapolates the prevalence in the present cohort of HCV-infected individuals, and assumes a stable low incidence in the projection period. We predict an almost three-fold increase in the incidence of cirrhosis (68 per 100,000), of decompensated cirrhosis (21 per 100,000) and of hepatocellular carcinoma (4 per 100,000) by 2050, as well as a six-fold increase in the cumulated number of deaths from HCV-related liver disease (170 per 100,000 inhabitants). All estimates are made assuming an unchanged treatment coverage of approximately 15%. The estimated numbers can be reduced by approximately 50% for cirrhosis, and by approximately one third for the other endpoints if treatment coverage is raised to 50%. Conclusion: These projections from a low-prevalence area indicate a substantial rise in HCV-related morbidity and mortality in the coming years. The global HCV epidemic is of great concern and increased treatment coverage is necessary to reduce the burden of the disease.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2017. Vol. 17, article id 624
Keywords [en]
Disease burden; Fibrosis development; Hepatitis C; Markov modelling; Natural course
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-141713DOI: 10.1186/s12879-017-2722-0ISI: 000410984800003PubMedID: 28915795OAI: oai:DiVA.org:liu-141713DiVA, id: diva2:1147319
Available from: 2017-10-05 Created: 2017-10-05 Last updated: 2017-11-29

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