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On decoration of biomolecular scaffolds with a conjugated polyelectrolyte
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Biotemplating is the art of using a biological structure as a scaffold which is decorated with a functional material. In this fashion the structures will gain new functionalities and biotemplating offers a simple route of mass-producing mesoscopic material with new interesting properties. Biological structures are abundant and come in a great variety of elaborate and due to their natural origin they could be more suitable for interaction with biological systems than wholly synthetic materials. Conducting polymers are a novel class of material which was developed just 40 years ago and are well suited for interaction with biological material due to their organic composition. Furthermore the electronic properties of the conducting polymers can be tuned giving rise to dynamic control of the behavior of the material. Self-assembly processes are interesting since they do not require complicated or energy demanding processing conditions. This is particularly important as most biological materials are unstable at elevated temperatures or harsh environments. The main aim of this thesis is to show the possibility of using self-assembly to decorate a conducting polymer onto various biotemplates. Due to the intrinsic variety in charge, size and structure between the available natural scaffolds it is difficult, if not impossible, to find a universal method.

In this thesis we show how biotemplating can be used to create new hybrid materials by self-assembling a conducting polymer with biological structures based on DNA, protein, lipids and cellulose, and in this fashion create material with novel optical and electronic properties.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2017. , p. 51
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1885
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-141675DOI: 10.3384/diss.diva-141675ISBN: 9789176854372 (print)OAI: oai:DiVA.org:liu-141675DiVA, id: diva2:1147005
Public defence
2017-10-19, Planck, Fysikhuset, Campus Valla, Linköping, 10:15 (English)
Opponent
Supervisors
Funder
Swedish Foundation for Strategic Research Knut and Alice Wallenberg FoundationAvailable from: 2017-10-04 Created: 2017-10-04 Last updated: 2017-10-05Bibliographically approved
List of papers
1. Functionalisation of recombinant spider silk with conjugated polyelectrolytes
Open this publication in new window or tab >>Functionalisation of recombinant spider silk with conjugated polyelectrolytes
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2011 (English)In: Journal of Materials Chemistry, ISSN 0959-9428, E-ISSN 1364-5501, Vol. 21, no 9, p. 2909-2915Article in journal (Refereed) Published
Abstract [en]

Conjugated polyelectrolytes are demonstrated to permit facile staining of recombinant spider silk fibres. We find that the polyelectrolyte concentration and pH of the staining solution as well as the incubation temperature strongly influence the efficiency of this self-assembly process, which appears to be principally mediated through favourable electrostatic interactions. Thus, depending on the choice of staining conditions as well as the polyelectrolyte, electrically conductive or photoluminescent recombinant silk fibres could be produced. In addition, staining of natural Bombyx mori silk is established, which emphasises the versatility of the here advanced approach to functionalise silk-based materials.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2011
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-66131 (URN)10.1039/c0jm03270k (DOI)000287369300019 ()
Available from: 2011-03-04 Created: 2011-03-04 Last updated: 2017-12-11
2. Electronic Polymers and DNA Self-assembled in Nanowire Transistors
Open this publication in new window or tab >>Electronic Polymers and DNA Self-assembled in Nanowire Transistors
2013 (English)In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 9, no 3, p. 363-368Article in journal (Refereed) Published
Abstract [en]

In this study the fully acidic form of PEDOT-S was used for the purpose of self-assembly onto DNA. We have previously shown that PEDOT-S is a short polymer that is self-doped with !1/3 of the sulfonate side groups acting as the self-doping sites (see supporting info.). The remaining sulfonate groups contribute to a net anionic charge, and a water-soluble polymer, with an intrinsic bulk conductivity of around 30 S/cm. It has been shown that PEDOT-S can bind to oppositely charged cationic amyloid protein structures in water and form conducting nano fibrillar networks, and it has also been shown to form hybrid structures with synthetic peptides, and gold nanoparticles.

Place, publisher, year, edition, pages
Wiley-VCH Verlag Berlin, 2013
Keywords
Organic electronics, conducting polymers, DNA nanotechnology, molecular selfassembly, organic electrochemical transistors
National Category
Natural Sciences Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-81344 (URN)10.1002/smll.201201771 (DOI)000314547200005 ()
Note

Funding Agencies|Strategic Research Foundation SSF through the program OPEN||

Available from: 2012-09-12 Created: 2012-09-12 Last updated: 2017-12-07Bibliographically approved
3. Electronic polymers in lipid membranes
Open this publication in new window or tab >>Electronic polymers in lipid membranes
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, no 11242Article in journal (Refereed) Published
Abstract [en]

Electrical interfaces between biological cells and man-made electrical devices exist in many forms, but it remains a challenge to bridge the different mechanical and chemical environments of electronic conductors (metals, semiconductors) and biosystems. Here we demonstrate soft electrical interfaces, by integrating the metallic polymer PEDOT-S into lipid membranes. By preparing complexes between alkyl-ammonium salts and PEDOT-S we were able to integrate PEDOT-S into both liposomes and in lipid bilayers on solid surfaces. This is a step towards efficient electronic conduction within lipid membranes. We also demonstrate that the PEDOT-S@alkyl-ammonium: lipid hybrid structures created in this work affect ion channels in the membrane of Xenopus oocytes, which shows the possibility to access and control cell membrane structures with conductive polyelectrolytes.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015
National Category
Biophysics
Identifiers
urn:nbn:se:liu:diva-120045 (URN)10.1038/srep11242 (DOI)000356090400002 ()26059023 (PubMedID)
Note

Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Research Council

Available from: 2015-07-06 Created: 2015-07-06 Last updated: 2018-01-25
4. Protein nanowires with conductive properties
Open this publication in new window or tab >>Protein nanowires with conductive properties
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2015 (English)In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 3, no 25, p. 6499-6504Article in journal (Refereed) Published
Abstract [en]

Herein we report on the investigation of self-assembled protein nanofibrils functionalized with metallic organic compounds. We have characterized the electronic behaviour of individual nanowires using conductive atomic force microscopy. In order to follow the self assembly process we have incorporated fluorescent molecules into the protein and used the energy transfer between the internalized dye and the metallic coating to probe the binding of the polyelectrolyte to the fibril.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-120179 (URN)10.1039/c5tc00896d (DOI)000356529100010 ()
Note

Funding Agencies|Knut and Alice Wallenberg Foundation through a Wallenberg Scholar grant

Available from: 2015-07-13 Created: 2015-07-13 Last updated: 2017-12-04
5. Conducting microhelices from self-assembly of protein fibrils
Open this publication in new window or tab >>Conducting microhelices from self-assembly of protein fibrils
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2017 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 13, no 25, p. 4412-4417Article in journal (Refereed) Published
Abstract [en]

Herein we utilize insulin to prepare amyloid based chiral heliceswith either right or left handed helicity. We demonstrate that thehelices can be utilized as structural templates for the conductingpolymer alkoxysulfonate poly(ethylenedioxythiophene) (PEDOT-S).The chirality of the helical assembly is transferred to PEDOT-S asdemonstrated by polarized optical microscopy (POM) and CircularDichroism (CD). Analysis of the helices by conductive atomic force(c-AFM) shows significant conductivity. In addition the morphologyof the template structure is stabilized by PEDOT-S. Theseconductive helical structures represent promising candidates in ourquest for THz resonators.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2017
National Category
Chemical Sciences
Identifiers
urn:nbn:se:liu:diva-137821 (URN)10.1039/c7sm00068e (DOI)000404564500001 ()28590474 (PubMedID)
Note

Funding agencies: Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [SFO-Mat-LiU 2009-00971]; Strategic Research Foundation through the project OPEN; Knut and Alice Wallenberg foundation; Wallenberg Scholar gran

Available from: 2017-05-31 Created: 2017-05-31 Last updated: 2017-10-04

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