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Designing an Experimental Protocol for Separating Active Diameter Response from Passive Response in Small Blood Vessels
KTH, School of Technology and Health (STH).
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Utveckling av ett experiment som separerar den aktiva och passiva diameter responsen hos små blodkärl (Swedish)
Abstract [en]

The knowledge of blood vessel biomechanics is used for understanding and developing treatments for cardiovascular disease. The objective of this project was to develop an experimental protocol, for education and research, that separates active diameter response from the passive, as a function of the intraluminal pressure in a pressure myograph.

The design process was performed in three steps. First the protocol was designed for an artificial vessel and then expanded to include passive properties of blood vessels, finally further developments needed to analyze active blood vessels were suggested. The system was built as a pressure myograph containing a vessel chamber where the vessel was mounted on two cannulas, two pressure sensors for calculating the intraluminal pressure, and one microscope equipped with a camera for diameter observations. Reference data for the artificial vessel material was acquired from a uniaxial tensile test.

The results was in the form of stress-stretch relations. Both the results from the artificial vessel and the passive blood vessel was in a acceptable reference range. The results indicate that the experimental protocol can be used for testing passive properties of both artificial vessels and small blood vessels. No results were obtained for active blood vessels, thus the experimental protocol can not be used for separating the active response to diameter change of blood vessels. However, further developments of the experimental protocol are discussed.

Abstract [sv]

Kunskap om blodkärlens biomekanik används för att förstå och utveckla behandlingsmetoder mot hjärt- och kärlsjukdomar. Syftet med det här projektet var att utveckla ett experiment som mäter små blodkärls diameter och vätsketryck in vitro. Experimentet skulle sedan separera det aktiva muskelbidraget till diameterförändring från det passiva bidraget. Genom att göra detta kan kunskapen om biomekaniken hos blodkärl utvecklas inom såväl forskning som utbildning.

Experimentet utvecklades i tre steg. Först utvecklades det för artificiella blodkärl och anpassades sedan för passiva blodkärl. Slutligen diskuteras vidareutvecklingar av experimentet gällande de aktiva egenskaperna för blodkärl. Experimentet utformades genom att ett kärl placerades i en kammare. Blodkärlet fästes i vardera ände på varsin kanyl som var kopplade till trycksensorer. För att registrera diametern placerades kammaren under ett kameramikroskop.

Resultatet består av spänning-sträcknings diagram. Både resultatet för det artificiella blodkärlet och det passiva blodkärlet var inom ett godkänt referensintervall. Dessa resultat stödjer antagandet att experimentet kan användas för att studera passiva egenskaper av artificiella och verkliga blodkärl med storlek mellan 1.9-4.4 mm i ytterdiameter. Ingen mätdata från aktiva blodkärl kunde samlas in, utan utvecklingskrav på systemet för hantering av aktiva blodkärl har föreslagits.

Place, publisher, year, edition, pages
2017. , 36 p.
Series
TRITA-STH, 2017:70
Keyword [en]
Experimental protocol, pressure myograph, vessel diameter, passive response, active response, artificial vessel, biomechanics
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-211726OAI: oai:DiVA.org:kth-211726DiVA: diva2:1130634
External cooperation
Solid Mechanics department, KTH
Subject / course
Medical Engineering
Educational program
Master of Science in Engineering - Medical Engineering
Supervisors
Examiners
Available from: 2017-08-10 Created: 2017-08-10 Last updated: 2017-08-10Bibliographically approved

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