Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. National Institute Pharmaceut Educ and Research Institute, India.
National Institute Pharmaceut Educ and Research Institute, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
National Institute Pharmaceut Educ and Research Institute, India; National Institute Pharmaceut Educ and Research Institute, India.
Show others and affiliations
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 3924Article in journal (Refereed) Published
Abstract [en]

Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation. The aim of the present study was to investigate the potential protective effect of intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation of 3 doses of uridine 1 mg/Kg (lower dose), 5 mg/Kg (medium dose), and 10 mg/Kg (higher dose) in saline was performed daily. Uridine at medium and high dose significantly reduced the severity of colitis (DAI score) and alleviated the macroscopic and microscopic signs of the disease. The levels of proinflammatory cytokines IL-6, IL-1 beta and TNF in serum as well as mRNA expression in colon were significantly reduced in the uridine treated groups. Moreover, colon tissue myloperoxidase activities, protein expression of IL-6, TNF-alpha, COX-2, P-NFkB and P-Ikk-alpha beta in the colon tissues were significantly reduced in medium and high dose groups. These findings demonstrated that local administration of uridine alleviated experimental colitis in male C57BL/6 mice accompanied by the inhibition of neutrophil infiltration and NF-kappa B signaling. Thus, Uridine may be a promising candidate for future use in the treatment of inflammatory bowel disease.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 7, 3924
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-139400DOI: 10.1038/s41598-017-04041-9ISI: 000403643900077PubMedID: 28634361OAI: oai:DiVA.org:liu-139400DiVA: diva2:1129890
Note

Funding Agencies|County Council of Ostergotland, Sweden

Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-27

Open Access in DiVA

fulltext(3961 kB)9 downloads
File information
File name FULLTEXT01.pdfFile size 3961 kBChecksum SHA-512
2c92f3d0285582b6b57a1866836e1017f57898bf5e9f4821f6c3d3f5d1e0e7ddedc86af50c4796c6707a262cd174f8a41e2168f8f54f217711fcbc78dba619f3
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kumar Jeengar, ManishMagnusson, MattiasUppugunduri, Srinivas
By organisation
Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Clinical Chemistry
In the same journal
Scientific Reports
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
Total: 9 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 76 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf