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Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET
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2017 (English)In: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, E-ISSN 1619-7089, Vol. 44, no Suppl 1, p. S4-S16Article, review/survey (Refereed) Published
Abstract [en]

In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent (18)F-fluorodeoxyglucose (FDG) activity. Also, hardware developments such as continuous bed motion (CBM), (digital) solid-state photodetectors and combined PET and magnetic resonance (MR) systems are explained. These novel techniques have a significant impact on cancer imaging, as they result in better image quality, improved small lesion detectability, and more accurate quantification of radiopharmaceutical uptake. This influences cancer diagnosis and staging, as well as therapy response monitoring and radiotherapy planning. Finally, the possible impact of these developments on the European Association of Nuclear Medicine (EANM) guidelines and EANM Research Ltd. (EARL) accreditation for FDG-PET/CT tumor imaging is discussed.

Place, publisher, year, edition, pages
2017. Vol. 44, no Suppl 1, p. S4-S16
Keywords [en]
Digital PET, EARL, Lesion detectability, PET/MR, Point-spread-function, Time-of-flight
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-327255DOI: 10.1007/s00259-017-3727-zISI: 000406753500002PubMedID: 28687866OAI: oai:DiVA.org:uu-327255DiVA, id: diva2:1129860
Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2018-02-16Bibliographically approved

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