Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
An ex vivo model using human peritoneum to explore mesh-tissue integration
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. (Clister)
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. (Clister)
Show others and affiliations
2017 (English)In: Biology open, ISSN 2046-6390, Vol. 6, no 9, p. 1391-1395Article in journal (Refereed) Published
Abstract [en]

Biological compatibility, in terms of implantation of foreign mesh material in hernia surgery, still needs experimental investigation. Present study develops an experimental model using human peritoneum to study the integration between tissue and different mesh material. The ex vivo model using peritoneal tissue was studied with different mesh material, and integration was monitored over time using microscopy.It could be demonstrated that the peritoneal model may be kept viable in culture for several weeks. Cell migration was seen after 7-10 days in culture and could be further monitored over several weeks. The use of a human artificial model environment enabling the investigation of tissue/mesh integration has, to our knowledge, not been described previously.This proof-of-concept model was developed, for the investigation of peritoneal biology and the integration between tissue and different mesh material. It has the potential to be useful in studies on other important biological mechanisms involving the peritoneum.

Place, publisher, year, edition, pages
2017. Vol. 6, no 9, p. 1391-1395
Keywords [en]
Experimental model, Peritoneum, Peritoneal tissue, Mesh, Synthetic mesh, Biocompatibility
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-138063DOI: 10.1242/bio.024992ISI: 000410919200017PubMedID: 28760734OAI: oai:DiVA.org:umu-138063DiVA, id: diva2:1129566
Available from: 2017-08-04 Created: 2017-08-04 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(3374 kB)16 downloads
File information
File name FULLTEXT01.pdfFile size 3374 kBChecksum SHA-512
748880485679ab72cfa5a69e404a8480a6ddbdf3619b49b9ac3b3d5ef696467d154e21f29fc35081a46f2c575f13d8280d095549be7b76b6fb15e324b27df52f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Strigård, KarinGunnarsson, Ulf
By organisation
Surgery
Surgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 16 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 100 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf