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Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
2017 (English)In: Journal of Oral Microbiology, ISSN 2000-2297, E-ISSN 2000-2297, Vol. 9, 1334504Article in journal (Refereed) Published
Abstract [en]

Background: The presence of Aggregatibacter actinomycetemcomitans in patients with periodontitis has been extensively studied for decades. Objective: To study the prevalence of A. actinomycetemcomitans in younger and older periodontitis patients and to genetically characterize isolates of this bacterium. Design: Data from microbiological analyses of 3459 subgingival plaque samples collected from 1445 patients, 337 'younger' patients (<= 35 yrs) and 1108 'older' patients (>35 yrs) during 15 years (2000-2014), has been summerized. Isolates of A. actinomycetemcomitans were serotyped, leukotoxin promoter typed (JP2 and non JP2) and arbitrarily primed PCR (APPCR) genotyped. The origin of the JP2 genotype detected in the study population was determined. Results: The prevalence of A. actinomycetemcomitans was higher among younger than older patients and samples from the younger patients contained higher proportions of the bacterium. Serotype b was more prevalent among younger patients and the majorty of these isolates was from the same AP-PCR genotype. The JP2 genotype was detected in 1.2% of the patients, and the majority of these carriers were of non-African origin. Conslusions: For presence and charcteristics of A. actinomycetemcomitans in clinical samples the age of the carriers were a discriminating factor. Additional, apparently non- African carriers of the JP2 genotype of A. actinomycetemcomitans were identified.

Place, publisher, year, edition, pages
Taylor & Francis, 2017. Vol. 9, 1334504
Keyword [en]
Aggregatibacter actinomycetemcomitans, leukotoxin, JP2, serotypes, AP-PCR genotypes, crobiological diagnostics
National Category
Microbiology in the medical area Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-137819DOI: 10.1080/20002297.2017.1334504ISI: 000404392200001OAI: oai:DiVA.org:umu-137819DiVA: diva2:1128537
Available from: 2017-07-26 Created: 2017-07-26 Last updated: 2017-07-26Bibliographically approved

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Claesson, RolfHöglund-Åberg, CarolaJohansson, Anders
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