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Increased levels of alveolar and airway exhaled nitric oxide in runners
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
Karolinska Inst, Dept Med; Karolinska Univ Hosp, Dept Cardiol.
Univ Torino, Div Resp Dis, Dept Clin & Biol Sci, Turin, Italy..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 2, 85-91 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The objective of this study was to apply extended NO analysis for measurements of NO dynamics in the lung, divided into alveolar and airway contribution, in amateur runners and marathoners. Methods: The athletes participated in either a marathon or a half marathon. The athletes self-reported their age, weight, height, training distance per week, competing distance, cardio-pulmonary health, atopic status, and use of tobacco. Measurements of exhaled NO (FENO) with estimation of alveolar NO (CANO) and airway flux (J(aw)NO), ventilation, pulse oximetry, and peak flow were performed before, immediately after, and 1hour after completing the race. Results: At baseline the alveolar NO was higher in amateur runners, 2.91.1ppb (p=0.041), and marathoners, 3.6 +/- 1.9ppb (p=0.002), than in control subjects, 1.4 +/- 0.5ppb. J(aw)NO was higher in marathoners, 0.90 +/- 0.02 nLs(-1) (p=0.044), compared with controls, 0.36 +/- 0.02 nLs(-1), whereas the increase in amateur runners, 0.56 +/- 0.02 nLs(-1), did not attain statistical significance (p=0.165). Immediately after the race there was a decrease in FENO in both amateur runners and marathoners, whereas CANO and J(aw)NO were decreased in marathoners only. Conclusion: Our results support the view that there is an adaptation of the lung to exercise. Thus strenuous exercise increased both airway and alveolar NO, and this might in turn facilitate oxygen uptake.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 122, no 2, 85-91 p.
Keyword [en]
Athletes, biomarkers, exhaled nitric oxide, pulmonary gas exchange
National Category
Physiology Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-323495DOI: 10.1080/03009734.2017.1317886ISI: 000401756500003PubMedID: 28481126OAI: oai:DiVA.org:uu-323495DiVA: diva2:1124449
Available from: 2017-07-13 Created: 2017-07-13 Last updated: 2017-07-13Bibliographically approved

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