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Fekal mikrobiell transplantation (FMT) vid fetma och metabolt syndrom
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2017 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

I Sverige lider 14% av befolkningen av fetma, och övervikt är ett växande hälsoproblem i hela västvärlden. Fetma kan leda till kardiovaskulära sjukdomar, och det finns idag ingen effektiv läkemedelsbehandling mot fetma. I djurstudier associeras fetma med förändringar i sammansättningen av tarmfloran samt metabola funktionen. Vårt hälsotillstånd speglas av mikrobiotans sammansättning som påverkas av miljöfaktorer. Manipulation av mikrobiotan i tarmen via fekal mikrobiell transplantation (FMT) skulle därför kunna vara ett behandlingsalternativ vid fetma och dess följdsjukdomar. Sådana djurstudier finns publicerade, samt en studie som genomförts på människor med metabolt syndrom där hälsoeffekter av FMT utvärderats. Syftet med denna litteraturstudie, som är läkemedelsinriktad, var att utvärdera om FMT skulle kunna ha en gynnsam effekt på tarmfloran hos individer med fetma och/eller metabolt syndrom. Av de åtta artiklarna kunde goda effekter av FMT utläsas vid behandling av fetma och metabolt syndrom. Kosten hade en betydelse för resultatet; vid en alltför, vad som anses ohälsosam kost, kunde inte en effekt av FMT utläsas. Det som gav positiva hälsoeffekter var butyratproducerande mikrobiota samt metanogener. Dock behöver fler studier göras för att ta reda på vilken roll tarmfloran har på kroppsvikt och energihomeostas, samt vilka roller olika mikrober har, för att få en effektiv sammansättning inför en FMT.

Abstract [en]

In Sweden, 14% of the population suffer from obesity, and it is a growing health problem throughout the western world. Obesity can lead to cardiovascular disease, and today there is no effective drug treatment for obesity. In animal studies, obesity is associated with changes in the composition of the intestinal flora and metabolic function. Our state of health is reflected by the composition of the microbiota, which is influenced by environmental factors. Thus, manipulation of the microbiota in the intestine via fecal microbial transplantation (FMT) could be a treatment option for obesity and its sequelae. Such animal studies are published, and there is one study conducted on humans with metabolic syndrome where the health effects of FMT was evaluated. The purpose of this literature study, which has a pharmaceutical focus, was to evaluate whether FMT could have a beneficial effect on the intestinal flora of individuals with obesity and/or metabolic syndrome. Of the eight articles, good effects of FMT could be seen in the treatment of obesity and metabolic syndrome. The food had a bearing on the result; with an, what is considered, unhealthy diet, an effect of FMT could not be seen. What gave positive health effects was butyrate producing microbiota as well as methanogens. However, more studies need to be done to find out what role the intestinal flora has on body weight and energy homeostasis, as well as what roles different microbiota have, to get an effective composition of microbes for FMT.

Place, publisher, year, edition, pages
2017. , 30 p.
Keyword [sv]
Fekal mikrobiell transplantation (FMT), fetma, metabolt syndrom, mikrobiota, tarmflora
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-66921OAI: oai:DiVA.org:lnu-66921DiVA: diva2:1123261
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Supervisors
Examiners
Available from: 2017-07-13 Created: 2017-07-12 Last updated: 2017-07-13Bibliographically approved

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