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Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events
Kings Coll London, Div Canc Studies, TOUR, London, England..
Kings Coll London, Div Canc Studies, TOUR, London, England.;Akad Sjukhuset, Reg Canc Ctr, Uppsala, Sweden..
Karolinska Inst, CLINTEC Dept, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden..
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2017 (English)In: International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, E-ISSN 1879-355X, Vol. 97, no 5, 1026-1031 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa).

Patients and Methods: We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age-and county-matched comparison cohort of PCa-free men (n = 46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression.

Results: Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis.

Conclusion: Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2017. Vol. 97, no 5, 1026-1031 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-324345DOI: 10.1016/j.ijrobp.2017.01.218ISI: 000401128500026PubMedID: 28332985OAI: oai:DiVA.org:uu-324345DiVA: diva2:1110295
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-5047Swedish Cancer Society
Available from: 2017-06-15 Created: 2017-06-15 Last updated: 2017-06-15Bibliographically approved

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