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An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves
Lund University. (EMBLA)ORCID iD: 0000-0001-7980-376X
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD: 0000-0002-7023-4772
Department Biomedical Engineering, Lund University.ORCID iD: 0000-0002-2399-8294
Department Biomedical Engineering, Lund University.ORCID iD: 0000-0003-1282-9580
Show others and affiliations
2017 (English)In: Biomicrofluidics, ISSN 1932-1058, E-ISSN 1932-1058, Vol. 11, 031101Article in journal (Refereed) Published
Abstract [en]

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped droplet-splitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

Place, publisher, year, edition, pages
2017. Vol. 11, 031101
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-324306DOI: 10.1063/1.4984131OAI: oai:DiVA.org:uu-324306DiVA: diva2:1109652
Funder
Knut and Alice Wallenberg Foundation, 2012.0023Swedish Research Council, 621-2013-5920The Crafoord Foundation, 20130569
Available from: 2017-06-14 Created: 2017-06-14 Last updated: 2017-06-14Bibliographically approved

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Fornell, AnnaOhlin, MathiasGarofalo, FabioNilsson, JohanTenje, Maria
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