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Synthesis and Characterization of Acrylfentanyl Metabolites
Linköping University, Department of Physics, Chemistry and Biology, Chemistry.
2017 (English)Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
Abstract [en]

Acrylfentanyl is a synthetic opioid that has been widely used in the last year. To help in the fight against synthetic drugs two potential metabolites of acrylfentanyl, one monohydroxy and one dihydroxy were synthesized. These metabolites will hopefully later be implemented in the analytical methods for metabolites of acrylfentanyl in urine by the Swedish National Board of Forensic Medicine.

To have metabolites for analysis are very important as they are the main target in drug testing.

The method used to synthesize the metabolites is a five-step synthesis with an additional 6th step for the dihydroxy metabolite. The methods used in the synthesis includes protection of amine with tert-butyloxycarbonyl, reductive amination with sodium triaceto boronhydride, alkylation and demethylation with boron tribromide. The methods used produced good results with high yields in nearly all steps.

Place, publisher, year, edition, pages
2017. , p. 20
Keywords [en]
Acrylfentanyl, Metabolite, Synthesis
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-138142ISRN: LiTH-IFM-G-EX--17/3321--SEOAI: oai:DiVA.org:liu-138142DiVA, id: diva2:1109572
Subject / course
Chemistry
Presentation
2017-05-31, Linköping, 14:20 (English)
Supervisors
Examiners
Available from: 2017-06-19 Created: 2017-06-14 Last updated: 2017-06-19Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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