Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy
University of Calif Irvine, CA 92715 USA.
University of Calif Irvine, CA 92715 USA.
University of Calif Irvine, CA 92715 USA.
University of Calif Irvine, CA 92715 USA.
Show others and affiliations
2017 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 22, no 4, 045003Article in journal (Refereed) Published
Abstract [en]

Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are modelbased near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, mu(a), and reduced scattering, mu(s)) and blood flow (blood flow index, BFI), respectively. DOSI-derived mu(a) values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin(HbO2,HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/ DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 mm(-1) (37%) in mu(s) and 0.003 mm(-1) (33%) in mu(a) lead to similar to 53% and 9% errors in BFI, respectively. DOSI/ DCS imaging of a solid tissue-simulating flow phantom and a breast cancer patient reveals well-defined spatial distributions of BFI and composition that clearly delineates both the flow channel and the tumor. BFI reconstructed with DOSI-corrected mu(a) and mu(s) values had a tumor/ normal contrast of 2.7, 50% higher than the contrast using commonly assumed fixed optical properties. In conclusion, spatially coregistered imaging of DOSI and DCS enhances intrinsic tumor contrast and information content. This is particularly important for imaging diseased tissues where there are significant spatial variations in mu(a) and mu(s) as well as potential uncoupling between flow and metabolism. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication,

Place, publisher, year, edition, pages
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS , 2017. Vol. 22, no 4, 045003
Keyword [en]
noninvasive; breast cancer; diffuse optical spectroscopy; oxygen metabolism; blood flow; diffuse correlation spectroscopy
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-138288DOI: 10.1117/1.JBO.22.4.045003ISI: 000400896100024PubMedID: 28384703OAI: oai:DiVA.org:liu-138288DiVA: diva2:1109066
Note

Funding Agencies|National Institute of Biomedical Imaging and Bioengineering [P41EB015890]; National Cancer Institute [R01CA142989, U54CA136400]; Chao Family Comprehensive Cancer Center [P30CA62203]; Arnold and Mabel Beckman Foundation; Fulbright Visiting Scholar grant; Swedish Governmental Agency for Innovation Systems (VINNOVA) [2015-0153]; NIH [P41-EB015893, 1R01NS060653]

Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-06-30

Open Access in DiVA

fulltext(4414 kB)10 downloads
File information
File name FULLTEXT01.pdfFile size 4414 kBChecksum SHA-512
e19f03d2be5d018e54e390107a9eee566c084475b73c9ff5c585b0020f0d08d6d0baf7aefd277a603fb61baab9e56971272c329c7382078e8d2f2a9d2fe848e4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Strömberg, Tomas
By organisation
Division of Biomedical EngineeringFaculty of Science & Engineering
In the same journal
Journal of Biomedical Optics
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 10 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 842 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf