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Timing of chromosomal alterations during tumour development
2017 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

During cancer development, tumour cells will accumulate a lot of both

somatic point mutations and copy number alterations. It is not

unusual that affected genes have a copy number that differs from the

usual two. Due to the loss of DNA repair mechanisms the cells can

mutate independent from each other which gives rise to different

subclones within the tumour. A tumour cell and its future daughter

cells that gets an advantage in cell division speed compared to its

competing neighbours, will eventually make up a large portion of the

tumour. All the mutations that the subclone’s most recent common

ancestor acquired until the expansion will be shared across the

subclone.

In this project, we have developed a method using the mutation

frequencies from publicly available whole genome sequencing data, to

quantify the amount of competing subclones in a sample and

determining the time to its copy number duplications. This method

could be further developed to be an extension to regular copy number

analysis.

A heterogeneous tumour can grow faster and be more resistant to

treatment. Therefore, it is important to learn more about cancer

development and get a greater understanding of the order in which

copy number alterations occur.

Place, publisher, year, edition, pages
2017. , 23 p.
Series
UPTEC X, 14 007
National Category
Bioinformatics (Computational Biology) Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-324157OAI: oai:DiVA.org:uu-324157DiVA: diva2:1108765
Supervisors
Examiners
Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-06-13Bibliographically approved

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Bioinformatics (Computational Biology)Engineering and Technology

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CiteExportLink to record
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