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Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
2017 (English)In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 5, 28Article in journal (Refereed) Published
Abstract [en]

Molecular tools for fluorescent imaging of specific compartments in cells are essential for understanding the function and activity of cells. Here, we report the synthesis of a series of pyridyl- and thienyl-substituted phospholes and the evaluation of these dyes for fluorescent imaging of cells. The thienyl-substituted phospholes proved to be successful for staining of cultured normal and malignant cells due to their fluorescent properties and low toxicity. Co-staining experiments demonstrated that these probes target lipid droplets, which are, lipid-storage organelles found in the cytosol of nearly all cell types. Our findings confirm that thienyl-substituted phospholes can be utilized as fluorescent tools for vital staining of cells, and we foresee that these fluorescent dyes might be used in studies to unravel the roles that lipid droplets play in cellular physiology and in diseases.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2017. Vol. 5, 28
Keyword [en]
phospholes; fluorescence; cells; imaging; lipid droplets
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:liu:diva-137859DOI: 10.3389/fchem.2017.00028ISI: 000400374400001PubMedID: 28487854OAI: oai:DiVA.org:liu-137859DiVA: diva2:1105050
Note

Funding Agencies|Swedish Foundation for Strategic Research

Available from: 2017-06-02 Created: 2017-06-02 Last updated: 2017-06-28

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