Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Quantitative MRI for analysis of peritumoral edema in malignant gliomas.
Department of Radiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden .
Department of Radiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, Department of Radiation Physics and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden .
Show others and affiliations
2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 5, e0177135Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Damage to the blood-brain barrier with subsequent contrast enhancement is a hallmark of glioblastoma. Non-enhancing tumor invasion into the peritumoral edema is, however, not usually visible on conventional magnetic resonance imaging. New quantitative techniques using relaxometry offer additional information about tissue properties. The aim of this study was to evaluate longitudinal relaxation R1, transverse relaxation R2, and proton density in the peritumoral edema in a group of patients with malignant glioma before surgery to assess whether relaxometry can detect changes not visible on conventional images.

METHODS: In a prospective study, 24 patients with suspected malignant glioma were examined before surgery. A standard MRI protocol was used with the addition of a quantitative MR method (MAGIC), which measured R1, R2, and proton density. The diagnosis of malignant glioma was confirmed after biopsy/surgery. In 19 patients synthetic MR images were then created from the MAGIC scan, and ROIs were placed in the peritumoral edema to obtain the quantitative values. Dynamic susceptibility contrast perfusion was used to obtain cerebral blood volume (rCBV) data of the peritumoral edema. Voxel-based statistical analysis was performed using a mixed linear model.

RESULTS: R1, R2, and rCBV decrease with increasing distance from the contrast-enhancing part of the tumor. There is a significant increase in R1 gradient after contrast agent injection (P < .0001). There is a heterogeneous pattern of relaxation values in the peritumoral edema adjacent to the contrast-enhancing part of the tumor.

CONCLUSION: Quantitative analysis with relaxometry of peritumoral edema in malignant gliomas detects tissue changes not visualized on conventional MR images. The finding of decreasing R1 and R2 means shorter relaxation times closer to the tumor, which could reflect tumor invasion into the peritumoral edema. However, these findings need to be validated in the future.

Place, publisher, year, edition, pages
2017. Vol. 12, no 5, e0177135
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-322901DOI: 10.1371/journal.pone.0177135ISI: 000402058800007PubMedID: 28542553OAI: oai:DiVA.org:uu-322901DiVA: diva2:1103881
Available from: 2017-05-31 Created: 2017-05-31 Last updated: 2017-08-10Bibliographically approved

Open Access in DiVA

fulltext(7281 kB)3 downloads
File information
File name FULLTEXT01.pdfFile size 7281 kBChecksum SHA-512
a8200db323d009c0e2b86bf8b8f52d19a9cfcd53f5b58a2bc0cd3e453f3ecd401efeb1b4e3d52dc6c79f5ef87fb8262bcb263d8d438fdff75e6d8873b6e5481e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, Elna-Marie
By organisation
Radiology
In the same journal
PLoS ONE
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 3 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf