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Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans
Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Otfried Muller Str 25, D-72076 Tubingen, Germany..
Univ Childrens Hosp Zurich, Child Dev Ctr, Zurich, Switzerland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 000-0002-8911-4068
Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Otfried Muller Str 25, D-72076 Tubingen, Germany.;German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen IDM, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany..
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2017 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 54, 170-174 p., 170e174Article in journal (Refereed) Published
Abstract [en]

Aging is associated with increases in hypothalamic-pituitary-adrenal (HPA) axis activity that can predispose to metabolic and cognitive impairments. We investigated in elderly and young subjects whether intranasal insulin administration to the human brain reduces early-sleep nadir concentrations of adrenocorticotropin and cortisol, that is, indicators of baseline HPA axis activity. In within-subject comparisons, intranasal insulin (160 IU) or placebo was administered to 14 elderly (mean age 70.0 years) and 30 young (23.6 years) healthy subjects before bedtime. Sleep was polysomno-graphically assessed and blood samples were repeatedly collected. Elderly compared with young participants displayed increased early-sleep cortisol concentrations (p < 0.04) and reductions in slow wave and REM sleep (p < 0.001). Insulin administration reduced cortisol levels between 2300 hours and 0020 hours in the elderly (p = 0.03) but not young participants (p = 0.56; p = 0.003 for interaction). Findings indicate that central nervous insulin acts as an inhibitory signal in basal HPA axis activity regulation and suggest that intranasal insulin may normalize sleep-associated stress axis activity in older age.

Place, publisher, year, edition, pages
2017. Vol. 54, 170-174 p., 170e174
Keyword [en]
Insulin, Brain, Sleep, Aging, Hypothalamic-pituitary-adrenal axis, Cortisol
National Category
Neurosciences Geriatrics
Identifiers
URN: urn:nbn:se:uu:diva-322080DOI: 10.1016/j.neurobiolaging.2017.03.006ISI: 000399501800018PubMedID: 28385552OAI: oai:DiVA.org:uu-322080DiVA: diva2:1096778
Funder
German Research Foundation (DFG), SFB 654
Available from: 2017-05-19 Created: 2017-05-19 Last updated: 2017-05-19Bibliographically approved

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