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GIFeGSH: A New Genomic Island Might Explain the Differences in Brucella Virulence
Public Health Agency of Sweden; Swedish Forum for Biopreparedness Diagnostics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
SVA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.ORCID iD: 0000-0002-2111-9751
2017 (English)In: Open Journal of Animal Sciences, ISSN 2161-7597, E-ISSN 2161-7627, Vol. 7, 141-148 p.Article in journal (Refereed) Published
Abstract [en]

An imported dog was confirmed to be positive with canine brucellosis in Sweden in 2010. The whole genome of Brucella canis SVA10 was subjected to phage analysis (WGS-PA) and was assigned to the Asian B. canis cluster. Further analysis indicated that the genome of B. canis SVA10 is smaller compared to genomes of the same species. A 35,781 bp genomic island (GI) was found to be absent in strain SVA10 which was detected by read mapping the paired reads to the genome of B. canisATCC 23,365T. The lacking genes of genomic island GIFeGSH are mainly coding for iron uptake enzymes and parts of the glutathione pathway. A screening of all available whole genome sequences of Brucella strains confirmed that GIFeGSH is also missing in four more strains of B. canis but present in several strains of B. abortusB. melitensisB. suisB. ovisB. microti, B. pinnipedialis, and B. cetiParts of the GI were present, but scattered in two other B. canis strains. The aim of this study was to find differences in the genomes of Brucella which might explain former described differences in virulence. The analysis was extended to all available Brucella genomes after the detection of a genomic island in strain SVA10.

Place, publisher, year, edition, pages
2017. Vol. 7, 141-148 p.
Keyword [en]
Zoonoses, Brucellosis, Brucella canis, Genomic Island
National Category
Infectious Medicine
Research subject
Molecular Genetics; Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-322358DOI: 10.4236/ojas.2017.72012OAI: oai:DiVA.org:uu-322358DiVA: diva2:1096770
Available from: 2017-05-19 Created: 2017-05-19 Last updated: 2017-05-24Bibliographically approved

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