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Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology. Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland.
Landspitali Natl Univ Hosp Iceland, Dept Immunol, Reykjavik, Iceland..
Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland..
Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland..
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2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 3, 340-345 p.Article in journal (Refereed) Published
Abstract [en]

Psoriasis is a chronic inflammatory skin disease with profound effects on patients' health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis.

Place, publisher, year, edition, pages
2017. Vol. 97, no 3, 340-345 p.
Keyword [en]
chronic plaque psoriasis, streptococcal throat infection, tonsillectomy, health-related quality of life, Psoriasis Disability Index, Psoriasis Life Stress Inventory
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:uu:diva-321153DOI: 10.2340/00015555-2562ISI: 000398919200006PubMedID: 27819714OAI: oai:DiVA.org:uu-321153DiVA: diva2:1096680
Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-05-18Bibliographically approved

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