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Synthesis of functional polylactide: Monomer synthesis scale-up and poly(ethylene glycol) functionalization
KTH, School of Chemical Science and Engineering (CHE).
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Syntes av funktionell polylaktid : Uppskalning av monomersyntes och funktionalisering med poyetylenglykol (Swedish)
Abstract [en]

This master’s degree project optimized the synthesis route to a functional lactide by increasing the total yield from 25 to 33 % and reducing the number of unit operations from 17 to 10. This was done by optimizing an existing synthetic pathway to better fit larger scale manufacturing. The monomer was also successfully copolymerized with ʟ-lactide and functionalized by attaching poly(ethylene glycol) units of varying chain lengths to the polylactide chain, which gives some antifouling properties to the copolymer. The resulting material, a functionalized polylactide, is an interesting material suitable for the use in medical implats, largely thanks to its versatility and ability to be tailored for a specific purpose.

Abstract [sv]

I detta examensarbete optimerades en syntesväg till en funktionaliserad laktid genom att öka utbytet från 25 till 33 % samt minska antalet enhetsoperationer från 17 till 10 st. Detta gjordes genom att anpassa en befintlig syntesväg till tillverkning i större skala. Monomeren sampolymeriserades även med ʟ-laktid och funktionaliserades genom att polyetylenglykol av varierande kedjelängd fästes till polylaktidkedjan, vilket gav en hämmande effekt på celladheransen till materialets yta. Det resulterande materialet: En funktionaliserad polylaktid, är ett intressant material som lämpar sig för användning i medicinska implantat, mycket tack vare sin mångsidighet och möjligheten att utforma materialen för specifika ändamål.

Place, publisher, year, edition, pages
2016.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-207175OAI: oai:DiVA.org:kth-207175DiVA: diva2:1096539
Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-05-18Bibliographically approved

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