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Plasma soluble Urokinase-Type Plasminogen activator receptor is not associated with neurological Outcome in Patients with aneurysmal subarachnoid hemorrhage
Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland..
Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland..
Tampere Univ Hosp, Dept Intens Care, Crit Care Med Res Grp, Tampere, Finland..
Univ Tampere, Tampere Univ Hosp, Fac Med & Life Sci, Immunopharmacol Res Grp, Tampere, Finland..
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2017 (English)In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 8, 144Article in journal (Refereed) Published
Abstract [en]

Object: Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen activator receptor (suPAR) has shown potential as a prognostic and as an inflammatory biomarker in a wide range of critical illnesses since it displays an association with overall immune system activation. This is the first time that suPAR has been evaluated as a prognostic biomarker in aSAH. Methods: In this prospective population-based study, plasma suPAR levels were measured in aSAH patients (n = 47) for up to 5 days. suPAR was measured at 0, 12, and 24 h after patient admission to the intensive care unit (ICU) and daily thereafter until he/ she was transferred from the ICU. The patients' neurological outcome was evaluated with the modified Rankin Scale (mRS) at 6 months after aSAH. Results: suPAR levels (n = 47) during the first 24 h after aSAH were comparable in groups with a favorable (mRS 0-2) or an unfavorable (mRS 3-6) outcome. suPAR levels during the first 24 h were not associated with the findings in the primary brain CT, with acute hydrocephalus, or with antimicrobial medication use during 5-days' follow-up. suPAR levels were associated with generally accepted inflammatory biomarkers (C-reactive protein, leukocyte count). Conclusion: Plasma suPAR level was not associated with either neurological outcome or selected clinical conditions. While suPAR is a promising biomarker for prognostication in several conditions requiring intensive care, it did not reveal any value as a prognostic biomarker after aSAH.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2017. Vol. 8, 144
Keyword [en]
aneurysmal subarachnoid hemorrhage, biomarkers, neurological outcome, secondary brain injury, soluble urokinase-type plasminogen activator receptor, neuroinflammation
National Category
Anesthesiology and Intensive Care Neurology
Identifiers
URN: urn:nbn:se:uu:diva-322178DOI: 10.3389/fneur.2017.00144ISI: 000399532800001PubMedID: 28458650OAI: oai:DiVA.org:uu-322178DiVA: diva2:1096141
Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-05-17Bibliographically approved

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