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Modular textile-enabled bioimpedance system for personalized health monitoring applications
KTH, School of Technology and Health (STH), Medical Engineering. Högskolan i Borås. (Medicinska sensorer, signaler och system (MSSS), Medical sensors, signals and systems (MSSS))ORCID iD: 0000-0002-6605-4998
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A growing number of factors, including costs, technological advancements, ageing populations, and medical errors, are leading industrialized countries to invest in research on alternative solutions to improve their health-care systems and increase patients’ quality of life. Personal health systems (PHS) examplify the use of information and communication technologies that enable a paradigm shift from the traditional hospital-centered healthcare delivery model toward a preventive and person-centered approach. PHS offer the means to monitor a patient’s health using wearable, portable or implantable systems that offer ubiquitous, unobtrusive biodata

acquisition, allowing remote monitoring of treatment and access to the patient’s status. Electrical bioimpedance (EBI) technology is non-invasive, quick and relatively affordable technique that can be used for assessing and monitoring different health conditions, e.g., body composition assessments for nutrition. When combined with state-of-the-art advances in sensors and textiles, EBI technologies are fostering the implementation of wearable bioimpedance monitors that use functional garments for personalized healthcare applications. This research work is

focused on the development of wearable EBI-based monitoring systems for ubiquitous health monitoring applications. The monitoring systems are built upon portable monitoring instrumentation and custom-made textile electrode garments.

Portable EBI-based monitors have been developed using the latest material technology and advances in system-on-chip technology. For instance, a portable EBI spectrometer has been validated against a commercial spectrometer for total body composition assessment using functional textile electrode garments. The development of wearable EBI-based monitoring units using functional garments and dry textile electrodes for body composition assessment and respiratory monitoring has been shown to be a feasible approach. The availability of these measurement systems indicates progress toward the real implementation of personalized healthcare systems.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2017. , p. 89
Series
TRITA-STH ; 2017:6
Keywords [en]
personal healthcare system, electrical bioimpedance, wearable sensors, pervasive monitoring, portable monitoring, body composition, chronic kidney disease, wireless sensor, ubiquitous, instrumentation
National Category
Medical Laboratory and Measurements Technologies
Research subject
Technology and Health
Identifiers
URN: urn:nbn:se:kth:diva-207135ISBN: 978-91-7729-377-4 (print)OAI: oai:DiVA.org:kth-207135DiVA, id: diva2:1096082
Public defence
2017-06-02, M402, Allégatan 1, Borås, 10:00 (English)
Opponent
Supervisors
Note

QC 20170517

Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-05-17Bibliographically approved
List of papers
1. An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications
Open this publication in new window or tab >>An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications
2008 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 29, no 6, p. S267-78Article in journal (Refereed) Published
Abstract [en]

The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-on-chip fully integrated electrical impedance spectrometer, which might allow the implementation of minimum-size instrumentation for electrical bioimpedance measurements. However, AD5933 as such is not suitable for most applications of electrical bioimpedance. In this work, we present a relatively simple analog front-end that adapts AD5933 to a four-electrode strategy, allowing its use in biomedical applications for the first time. The resulting impedance measurements exhibit a very good performance in aspects like load dynamic range and accuracy. This type of minimum-size, system-on-chip-based bioimpedance measurement system would lead researchers to develop and implement light and wearable electrical bioimpedance systems for home and personal health monitoring applications, a new and huge niche for medical technology development.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2008
Keywords
electrical bioimpedance spectroscopy; system-on-chip; four-electrode method
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-73057 (URN)10.1088/0967-3334/29/6/S23 (DOI)000257167200024 ()18544823 (PubMedID)
Note
QC 20120208Available from: 2012-02-08 Created: 2012-02-01 Last updated: 2017-12-08Bibliographically approved
2. AD5933-based spectrometer for electrical bioimpedance applications
Open this publication in new window or tab >>AD5933-based spectrometer for electrical bioimpedance applications
2010 (English)Conference paper, Published paper (Refereed)
Abstract [en]

To build an Electrical Bioimpedance (EBI) spectrometer using the Impedance Measurement System-On-Chip AD5933 together with a 4-Electrode Analog Front End (4E-AFE) has been proven practicable. Such small measurement devices can make possible several new applications of EBI technology, especially when combined with functional textiles, which can enable wearable applications for personal health and home monitoring. After the implementation and functional validation of the 4E-AFE-enabled spectrometer, the next natural step is to validate for which EBI applications the 4E-AFE-enabled system is suitable. To test the applicability of this novel spectrometer on several EBI applications, 2R1C equivalent models have been experimentally obtained and impedance spectroscopy measurements have been performed with the system under study and with the SFB7 EBI spectrometer manufactured by ImpediMed. The 2R1C circuit parameters have been estimated with the BioImp software from the spectra obtained with both EBI spectrometers and the estimated values have been compared with the original values used in each circuit model implementation. The obtained results indicated that the 4E-AFE-enabled system cannot beat the performance of the SFB7 in accuracy but it performs better in preciseness. In any case the overall performance indicates that the 4E-AFE-enabled system can perform spectroscopy measurements in the frequency range from 5 to 100 kHz.

Place, publisher, year, edition, pages
IOP Publishing, 2010
Series
Journal of Physics: Conference Series, ISSN 1742-6588
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-74410 (URN)10.1088/1742-6596/224/1/012011 (DOI)2-s2.0-77954670339 (Scopus ID)
Conference
International Conference on Electrical Bioimpedance
Note
QC 20120206Available from: 2012-02-06 Created: 2012-02-03 Last updated: 2017-05-17Bibliographically approved
3. AD5933-based electrical bioimpedance spectrometer: Towards textile-enabled applications
Open this publication in new window or tab >>AD5933-based electrical bioimpedance spectrometer: Towards textile-enabled applications
2011 (English)In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2011, Vol. 2011, p. 3282-3285Conference paper, Published paper (Refereed)
Abstract [en]

Advances on System-On-Chip and Textile technology allows the development of Textile-enabled measurement instrumentation. Textile Electrodes (Textrodes) have been proven reliable for performing Electrical Bioimpedance Spectroscopy (EBIS) measurements, and the availability of a integrated circuit impedance spectrometer, the AD5933, has allowed the implementation of small size EBIS spectrometers. In this work an AD5933-based spectrometer has been implemented, and its performance on 2R1C circuits and for tetrapolar total right side EBIS measurements has been compared against the commercially available spectrometer SFB7. The study has been focused on the working upper frequency range and the estimation of the Cole parameters required for assessment of body fluid distribution: R(0) and R(∞). The results indicate that AD5933-based spectrometer implemented in this work can perform accurate impedance measurements well above the upper limits recommended in the datasheet. The AD5933-EBIS presents a good performance compared with the SFB7 on the 2R1C circuit and the total right side measurements, showing a smaller error in the resistance spectrum and small deviation error in the reactance when measuring over 270 kHz. The comparison on the Cole parameters estimation obtained with the SFB7 and the AD5933-based spectrometer exhibit a difference below 1% for the estimation of R(0) and R(∞). Consequently the overall measurement performance shown by the implemented AD5933-based spectrometer suggests its feasible use for EBIS measurements using dry Textrodes. This is of special relevance for the proliferation of EBI-based personalized health monitoring systems for patients that require to monitor the distribution of body fluids, like in dialysis.

National Category
Other Medical Engineering
Identifiers
urn:nbn:se:kth:diva-69633 (URN)10.1109/IEMBS.2011.6090891 (DOI)22255040 (PubMedID)2-s2.0-84055212203 (Scopus ID)
Conference
33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011; Boston, MA; 30 August 2011 through 3 September 2011
Note
QC 20120203Available from: 2012-01-29 Created: 2012-01-29 Last updated: 2017-05-17Bibliographically approved
4. A handheld and textile-enabled bioimpedance system for ubiquitous body composition analysis.: An initial functional validation
Open this publication in new window or tab >>A handheld and textile-enabled bioimpedance system for ubiquitous body composition analysis.: An initial functional validation
2016 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208Article in journal (Refereed) Published
Abstract [en]

In recent years, many efforts have been made to promote a healthcare paradigm shift from the traditional reactive hospital-centered healthcare approach towards a proactive, patient-oriented and self-managed approach that could improve service quality and help reduce costs while contributing to sustainability. Managing and caring for patients with chronic diseases accounts over 75% of healthcare costs in developed countries. One of the most resource demanding diseases is chronic kidney disease (CKD), which often leads to a gradual and irreparable loss of renal function, with up to 12% of the population showing signs of different stages of this disease. Peritoneal dialysis and home haemodialysis are life-saving home-based renal replacement treatments that, compared to conventional in-center hemodialysis, provide similar long-term patient survival, less restrictions of life-style, such as a more flexible diet, and better flexibility in terms of treatment options and locations. Bioimpedance has been largely used clinically for decades in nutrition for assessing body fluid distributions. Moreover, bioimpedance methods are used to assess the overhydratation state of CKD patients, allowing clinicians to estimate the amount of fluid that should be removed by ultrafiltration. In this work, the initial validation of a handheld bioimpedance system for the assessment of body fluid status that could be used to assist the patient in home-based CKD treatments is presented. The body fluid monitoring system comprises a custom-made handheld tetrapolar bioimpedance spectrometer and a textile-based electrode garment for total body fluid assessment. The system performance was evaluated against the same measurements acquired using a commercial bioimpedance spectrometer for medical use on several voluntary subjects. The analysis of the measurement results and the comparison of the fluid estimations indicated that both devices are equivalent from a measurement performance perspective, allowing for its use on ubiquitous e-healthcare dialysis solutions.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2016
Keywords
wireless, bioimpedance, body composition, electrodes, garment, home care, instrumentation, personalized healthcare, proactive care, self-managed care, sensor, textiles, wearable
National Category
Medical Engineering
Research subject
Applied Medical Technology
Identifiers
urn:nbn:se:kth:diva-199440 (URN)10.1109/JBHI.2016.2628766 (DOI)000409521700004 ()2-s2.0-85029926607 (Scopus ID)
Note

QC 20170119

Available from: 2017-01-08 Created: 2017-01-08 Last updated: 2017-10-20Bibliographically approved
5. Portable bioimpedance monitor evaluation for continuous impedance measurements: Towards wearable plethysmography applications
Open this publication in new window or tab >>Portable bioimpedance monitor evaluation for continuous impedance measurements: Towards wearable plethysmography applications
2013 (English)In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2013, p. 559-562Conference paper, Published paper (Refereed)
Abstract [en]

Personalised Health Systems (PHS) that could benefit the life quality of the patients as well as decreasing the health care costs for society among other factors are arisen. The purpose of this paper is to study the capabilities of the System-on-Chip Impedance Network Analyser AD5933 performing high speed single frequency continuous bioimpedance measurements. From a theoretical analysis, the minimum continuous impedance estimation time was determined, and the AD5933 with a custom 4-Electrode Analog Front-End (AFE) was used to experimentally determine the maximum continuous impedance estimation frequency as well as the system impedance estimation error when measuring a 2R1C electrical circuit model. Transthoracic Electrical Bioimpedance (TEB) measurements in a healthy subject were obtained using 3M gel electrodes in a tetrapolar lateral spot electrode configuration. The obtained TEB raw signal was filtered in MATLAB to obtain the respiration and cardiogenic signals, and from the cardiogenic signal the impedance derivative signal (dZ/dt) was also calculated. The results have shown that the maximum continuous impedance estimation rate was approximately 550 measurements per second with a magnitude estimation error below 1% on 2R1C-parallel bridge measurements. The displayed respiration and cardiac signals exhibited good performance, and they could be used to obtain valuable information in some plethysmography monitoring applications. The obtained results suggest that the AD5933-based monitor could be used for the implementation of a portable and wearable Bioimpedance plethysmograph that could be used in applications such as Impedance Cardiography. These results combined with the research done in functional garments and textile electrodes might enable the implementation of PHS applications in a relatively short time from now.

Series
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, ISSN 1557-170X
Keywords
Bioimpedance measurement, Electrical bio-impedance, Electrical circuit models, Electrode configurations, Impedance cardiography, Impedance measurement, Monitoring applications, Personalised health systems, Application specific integrated circuits, Biomedical equipment, Electric impedance measurement, Electric network analysis, Electrodes, Frequency estimation, Plethysmography, Electric impedance
National Category
Medical Engineering
Identifiers
urn:nbn:se:kth:diva-140000 (URN)10.1109/EMBC.2013.6609561 (DOI)2-s2.0-84886466230 (Scopus ID)9781457702167 (ISBN)
Conference
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013; Osaka, Japan, 3-7 July 2013
Note

QC 20140117

Available from: 2014-01-17 Created: 2014-01-16 Last updated: 2017-05-17Bibliographically approved
6. Wearable Biomedical Measurement Systems for Assessment of Mental Stress of Combatants in Real Time
Open this publication in new window or tab >>Wearable Biomedical Measurement Systems for Assessment of Mental Stress of Combatants in Real Time
Show others...
2014 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 14, no 4, p. 7120-7141Article in journal (Refereed) Published
Abstract [en]

The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants' operational capabilities. Within this framework the ATREC project funded by the Coincidente program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems.

Keywords
bioimpedance, GSR, heart rate, mental stress, non-invasive measurements, textile electrodes, speech analysis, multimodal signal processing
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:kth:diva-147966 (URN)10.3390/s140407120 (DOI)000336784600077 ()2-s2.0-84927172992 (Scopus ID)
Note

QC 20140710

Available from: 2014-07-10 Created: 2014-07-10 Last updated: 2017-12-05Bibliographically approved
7. Assessment of Mental, Emotional and Physical Stress through Analysis of Physiological Signals Using Smartphones
Open this publication in new window or tab >>Assessment of Mental, Emotional and Physical Stress through Analysis of Physiological Signals Using Smartphones
Show others...
2015 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, no 10, p. 25607-25627Article in journal (Refereed) Published
Abstract [en]

Determining the stress level of a subject in real time could be of special interest in certain professional activities to allow the monitoring of soldiers, pilots, emergency personnel and other professionals responsible for human lives. Assessment of current mental fitness for executing a task at hand might avoid unnecessary risks. To obtain this knowledge, two physiological measurements were recorded in this work using customized non-invasive wearable instrumentation that measures electrocardiogram (ECG) and thoracic electrical bioimpedance (TEB) signals. The relevant information from each measurement is extracted via evaluation of a reduced set of selected features. These features are primarily obtained from filtered and processed versions of the raw time measurements with calculations of certain statistical and descriptive parameters. Selection of the reduced set of features was performed using genetic algorithms, thus constraining the computational cost of the real-time implementation. Different classification approaches have been studied, but neural networks were chosen for this investigation because they represent a good tradeoff between the intelligence of the solution and computational complexity. Three different application scenarios were considered. In the first scenario, the proposed system is capable of distinguishing among different types of activity with a 21.2% probability error, for activities coded as neutral, emotional, mental and physical. In the second scenario, the proposed solution distinguishes among the three different emotional states of neutral, sadness and disgust, with a probability error of 4.8%. In the third scenario, the system is able to distinguish between low mental load and mental overload with a probability error of 32.3%. The computational cost was calculated, and the solution was implemented in commercially available Android-based smartphones. The results indicate that execution of such a monitoring solution is negligible compared to the nominal computational load of current smartphones.

Place, publisher, year, edition, pages
MDPI AG, 2015
Keywords
physiological measurements, smart textiles, smartphone, ECG, bioimpedance, stress detection, ergonomics
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-179614 (URN)10.3390/s151025607 (DOI)000364242300048 ()26457710 (PubMedID)2-s2.0-84943742389 (Scopus ID)
Note

QC 20160111

Available from: 2016-01-11 Created: 2015-12-17 Last updated: 2017-12-01Bibliographically approved

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