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Olfactory Impairment in Parkinson's Disease Studied with Diffusion Tensor and Magnetization Transfer Imaging.
Department of Radiology and Department ofMedical and Health Sciences, Linköping University; Center for Medical ImageScience and Visualization (CMIV), Linköping University.
Center for Medical ImageScience and Visualization (CMIV), Linköping University; SyntheticMR AB .
Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University.
Center for Medical ImageScience and Visualization (CMIV), Linköping University; Department of Clinical Physiology and Departmentof Medical and Health Sciences, Linköping University, Linköping.
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2017 (English)In: Journal of Parkinson's Disease, ISSN 1877-7171, E-ISSN 1877-718X, Vol. 7, no 2, 301-311 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Olfactory impairment is an early manifestation of Parkinson's disease (PD). Diffusion Tensor Imaging (DTI) and Magnetization Transfer (MT) are two imaging techniques that allow noninvasive detection of microstructural changes in the cerebral white matter.

OBJECTIVE: To assess white matter alterations associated with olfactory impairment in PD, using a binary imaging approach with DTI and MT.

METHODS: 22 PD patients and 13 healthy controls were examined with DTI, MT and an odor discrimination test. DTI data were first analyzed with tract-based spatial statistics (TBSS) in order to detect differences in fractional anisotropy, mean, radial and axial diffusivity between PD patients and controls. Voxelwise randomized permutation was employed for the MT analysis, after spatial and intensity normalization. Additionally, ROI analysis was performed on both the DTI and MT data, focused on the white matter adjacent to olfactory brain regions.

RESULTS: Whole brain voxelwise analysis revealed decreased axial diffusivity in the left uncinate fasciculus and the white matter adjacent to the left olfactory sulcus of PD patients. ROI analysis demonstrated decreased axial diffusivity in the right orbitofrontal cortex, as well as decreased mean diffusivity and axial diffusivity in the white matter of the left entorhinal cortex of PD patients. There were no significant differences regarding fractional anisotropy, radial diffusivity or MT between patients and controls.

CONCLUSIONS: ROI analysis of DTI could detect microstructural changes in the white matter adjacent to olfactory areas in PD patients, whereas MT imaging could not.

Place, publisher, year, edition, pages
2017. Vol. 7, no 2, 301-311 p.
Keyword [en]
Parkinson disease, diffusion tensor imaging, magnetization transfer contrast imaging, smell
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-322143DOI: 10.3233/JPD-161060ISI: 000401801600010PubMedID: 28482644OAI: oai:DiVA.org:uu-322143DiVA: diva2:1095995
Available from: 2017-05-16 Created: 2017-05-16 Last updated: 2017-06-16Bibliographically approved

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