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Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
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2017 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 116, no 5, p. 688-696Article in journal (Refereed) Published
Abstract [en]

Background: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n = 106, IHDB n = 34, GBTC n = 96) and their matched controls (1: 1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. Results: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR = 0.36; 95% CI: 0.13-0.98, Ptrend = 0.0123), but no association for copper (OR = 1.06; 95% CI: 0.45-2.46, Ptrend = 0.8878) in multivariable models. The calculated Cu/ Zn ratio showed a positive association for HCC (OR = 4.63; 95% CI: 1.41-15.27, Ptrend = 0.0135). For IHBC and GBTC, no significant associations were observed. Conclusions: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 116, no 5, p. 688-696
Keywords [en]
copper, zinc, hepatocellular carcinoma, prospective cohort, nested case-control study, cancer risk factors
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-133525DOI: 10.1038/bjc.2017.1ISI: 000395696200017PubMedID: 28152549OAI: oai:DiVA.org:umu-133525DiVA, id: diva2:1095612
Available from: 2017-05-15 Created: 2017-05-15 Last updated: 2018-06-09Bibliographically approved

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Weiderpass, ElisabeteWerner, Mårten
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