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The temporal basis of angiogenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Harvard Med Sch, Beth Israel Deaconess Med Ctr, Computat Biol Lab, Boston, MA USA.. (Lena Claesson Welsh)ORCID iD: 0000-0002-9391-659x
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Computat Biol Lab, Boston, MA USA..
2017 (English)In: Philosophical Transactions of the Royal Society of London. Biological Sciences, ISSN 0962-8436, E-ISSN 1471-2970, Vol. 372, no 1720, p. 1-11, article id 20150522Article in journal (Refereed) Published
Abstract [en]

The process of new blood vessel growth (angiogenesis) is highly dynamic, involving complex coordination of multiple cell types. Though the process must carefully unfold over time to generate functional, well-adapted branching networks, we seldom hear about the time-based properties of angiogenesis, despite timing being central to other areas of biology. Here, we present a novel, time-based formulation of endothelial cell behaviour during angiogenesis and discuss a flurry of our recent, integrated in silico/in vivo studies, put in context to the wider literature, which demonstrate that tissue conditions can locally adapt the timing of collective cell behaviours/decisions to grow different vascular network architectures. A growing array of seemingly unrelated 'temporal regulators' have recently been uncovered, including tissue derived factors (e.g. semaphorins or the high levels of VEGF found in cancer) and cellular processes (e.g. asymmetric cell division or filopodia extension) that act to alter the speed of cellular decisions to migrate. We will argue that 'temporal adaptation' provides a novel account of organ/disease-specific vascular morphology and reveals 'timing' as a new target for therapeutics. We therefore propose and explain a conceptual shift towards a 'temporal adaptation' perspective in vascular biology, and indeed other areas of biology where timing remains elusive. This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'.

Place, publisher, year, edition, pages
2017. Vol. 372, no 1720, p. 1-11, article id 20150522
Keywords [en]
time, dynamics, morphogenesis, adaptation, active perception, vascular
National Category
Medical Genetics Developmental Biology Cell and Molecular Biology Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-321167DOI: 10.1098/rstb.2015.0522ISI: 000397882500008OAI: oai:DiVA.org:uu-321167DiVA, id: diva2:1095511
Funder
Knut and Alice Wallenberg FoundationAvailable from: 2017-05-15 Created: 2017-05-15 Last updated: 2018-01-13Bibliographically approved

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