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Evolution and Prospects of the Asymmetric Hydrogenation of Unfunctionalized Olefins
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Number of Authors: 22017 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 139, no 4, p. 1346-1356Article in journal (Refereed) Published
Abstract [en]

The catalytic enantioselective hydrogenation of prochiral olefins is a key reaction in asymmetric synthesis. Its relevance applies to both industry and academia as an inherently direct and sustainable strategy to induce chirality. Here we briefly recount the early breakthroughs concerning the asymmetric hydrogenation of largely unfunctionalized olefins, from the first reports to the advent of chiral Crabtree-like catalysts. The mechanism and its implications on the enantioselectivity are shortly discussed. The main focus of this Perspective lies on the more recent advances in the field, such as the latest developed classes of ligands and the opportunity to employ more Earth-abundant metals. Therefore, separate sections consider iridium N,P-, NHC-, P,S-, and O,P catalysts, and rhodium, palladium, cobalt, and iron catalysts. Finally, the remaining unsolved challenges are examined, and the potential directions of forthcoming research are outlined.

Place, publisher, year, edition, pages
2017. Vol. 139, no 4, p. 1346-1356
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-141378DOI: 10.1021/jacs.6b10690ISI: 000393355600001PubMedID: 28064490OAI: oai:DiVA.org:su-141378DiVA, id: diva2:1091936
Funder
Knut and Alice Wallenberg FoundationStiftelsen Olle Engkvist ByggmästareAvailable from: 2017-04-28 Created: 2017-04-28 Last updated: 2018-05-18Bibliographically approved

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