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Affibody molecules as engineered protein drugs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Affibody AB, Gunnar Asplunds Alle 24, SE-17169 Solna, Sweden..
AbClon Inc, Seoul, South Korea..
2017 (English)In: Experimental and Molecular Medicine, ISSN 1226-3613, E-ISSN 2092-6413, Vol. 49, article id e306Article, review/survey (Refereed) Published
Abstract [en]

Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on diagnostic and therapeutic use of this molecular class of alternative scaffolds, and early clinical evidence is now beginning to accumulate that suggests the Affibody molecules to be efficacious and safe in man. The small size and ease of engineering make Affibody molecules suitable for use in multispecific constructs where AffiMabs is one such that offers the option to potentiate antibodies for use in complex disease.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 49, article id e306
National Category
Cell and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-320965DOI: 10.1038/emm.2017.35ISI: 000397275000009PubMedID: 28336959OAI: oai:DiVA.org:uu-320965DiVA, id: diva2:1091785
Available from: 2017-04-28 Created: 2017-04-28 Last updated: 2018-01-13Bibliographically approved

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