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Experimental evolution of slowed cognitive aging in Drosophila melanogaster
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ Lausanne, Dept Ecol & Evolut, CH-1015 Lausanne, Switzerland..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Univ Lausanne, Dept Ecol & Evolut, CH-1015 Lausanne, Switzerland..
Univ Lausanne, Dept Ecol & Evolut, CH-1015 Lausanne, Switzerland.;Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland..
2017 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 71, no 3, 662-670 p.Article in journal (Refereed) Published
Abstract [en]

Reproductive output and cognitive performance decline in parallel during aging, but it is unknown whether this reflects a shared genetic architecture or merely the declining force of natural selection acting independently on both traits. We used experimental evolution in Drosophila melanogaster to test for the presence of genetic variation for slowed cognitive aging, and assess its independence from that responsible for other traits' decline with age. Replicate experimental populations experienced either joint selection on learning and reproduction at old age (Old + Learning), selection on late-life reproduction alone (Old), or a standard two-week culture regime (Young). Within 20 generations, the Old + Learning populations evolved a slower decline in learning with age than both the Old and Young populations, revealing genetic variation for cognitive aging. We found little evidence for a genetic correlation between cognitive and demographic aging: although the Old + Learning populations tended to show higher late-life fecundity than Old populations, they did not live longer. Likewise, selection for late reproduction alone did not result in improved late-life learning. Our results demonstrate that Drosophila harbor genetic variation for cognitive aging that is largely independent from genetic variation for demographic aging and suggest that these two aspects of aging may not necessarily follow the same trajectories.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 71, no 3, 662-670 p.
Keyword [en]
Cognitive aging, Drosophila, experimental evolution, genetic architecture, learning, trade-off
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-320841DOI: 10.1111/evo.13156ISI: 000396039000011PubMedID: 28000915OAI: oai:DiVA.org:uu-320841DiVA: diva2:1091427
Funder
The Royal Swedish Academy of SciencesSwedish Research CouncilEU, European Research Council
Available from: 2017-04-26 Created: 2017-04-26 Last updated: 2017-09-07Bibliographically approved
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