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GATE simulation of a new design of pinhole SPECT system for small animal brain imaging
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, Boston, MA 02115 USA.;Near East Univ, TRNC, Dept Biomed Engn, Near East Blvd, CY-99138 Nicosia, Cyprus..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, Boston, MA 02115 USA.
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, Boston, MA 02115 USA..
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, Boston, MA 02115 USA..
2017 (English)In: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 12, article id C01085Article in journal (Refereed) Published
Abstract [en]

Small animal SPECT imaging has gained an increased interest over the past decade since it is an excellent tool for developing new drugs and tracers. Therefore, there is a huge effort on the development of cost-effective SPECT detectors with high capabilities. The aim of this study is to simulate the performance characteristics of new designs for a cost effective, stationary SPECT system dedicated to small animal imaging with a focus on mice brain. The conceptual design of this SPECT system platform, Stationary Small Animal SSA-SPECT, is to use many pixelated CsI:TI detector modules with 0.4 mm x 0.4 mm pixels in order to achieve excellent intrinsic detector resolution where each module is backed by a single pinhole collimator with 0.3 mm hole diameter. In this work, we present the simulation results of four variations of the SSA-SPECT platform where the number of detector modules and FOV size is varied while keeping the detector size and collimator hole size constant. Using the NEMA NU-4 protocol, we performed spatial resolution, sensitivity, image quality simulations followed by a Derenzo-like phantom evaluation. The results suggest that all four SSA-SPECT systems can provide better than 0.063% system sensitivity and < 1.5 mm FWHM spatial resolution without resolution recovery or other correction techniques. Specifically, SSA-SPECT-1 showed a system sensitivity of 0.09% in combination with 1.1 mm FWHM spatial resolution.

Place, publisher, year, edition, pages
2017. Vol. 12, article id C01085
Keywords [en]
Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA), Gamma detectors (scintillators, CZT, HPG, HgI etc), Medical-image reconstruction methods and algorithms, computer-aided software
National Category
Physical Sciences Medical Engineering
Identifiers
URN: urn:nbn:se:uu:diva-319859DOI: 10.1088/1748-0221/12/01/C01085ISI: 000395768300085OAI: oai:DiVA.org:uu-319859DiVA, id: diva2:1089632
Conference
14th Topical Seminar on Innovative Particle and Radiation Detectors, OCT 03-06, 2016, Siena, ITALY
Funder
Swedish Research CouncilAvailable from: 2017-04-20 Created: 2017-04-20 Last updated: 2018-02-22Bibliographically approved

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