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Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele
Lund Univ, Dept Translat Med, Jan Waldenstroms Gata 35,Bldg 91,Plan 10, S-20502 Malmo, Sweden..
Skane Univ Hosp, Dept Urol, Malmo, Sweden..
Lund Univ, Dept Orthoped & Clin Sci, Malmo, Sweden..
Lund Univ, Dept Translat Med, Jan Waldenstroms Gata 35,Bldg 91,Plan 10, S-20502 Malmo, Sweden..
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2017 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 28, no 3, 227-233 p.Article in journal (Refereed) Published
Abstract [en]

In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based cancer diagnosis. Using data from two population-based cohorts; the Malmo Diet and Cancer Study (MDCS, n = 12,121) and the Swedish Osteoporotic fractures in men study (MrOS, n = 1,120), 628 men with PCa and 1,374 controls were identified and genotyped. PCa data were collected from the Swedish national cancer registry. PCa odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for carriers of the particular AR haplotype, tagged by the rs6624304 T-allele. The 15% of men who were carriers of the AR haplotype H2 had approximately one-third lower risk for PCa diagnosis compared to those with the most common H1 variant (OR 0.65; 95% CI 0.45-0.94; p = 0.021). The same trend, although not statistically significant (OR 0.75; 95% CI 0.47-1.24; p = 0.275), was observed in MrOS Sweden. When both cohorts were merged, an even more significant result was observed (OR 0.68; 95% CI 0.51-0.90; p = 0.008). Swedish men with the variant AR haplotype H2, tagged by rs6624304, have significantly lower risk of PCa compared to those with the more common variant.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 28, no 3, 227-233 p.
Keyword [en]
Androgen receptor, Prostate cancer, Genetic variants
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-320347DOI: 10.1007/s10552-017-0859-1ISI: 000394986000005PubMedID: 28176139OAI: oai:DiVA.org:uu-320347DiVA: diva2:1089323
Funder
Swedish Cancer Society, CAN 2014/360
Available from: 2017-04-19 Created: 2017-04-19 Last updated: 2017-04-19Bibliographically approved

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