Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma
Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden..
Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden..
Masaryk Mem Canc Inst, RECAMO, Brno 65653, Czech Republic..
Umea Univ, Dept Clin Sci ENT, SE-90185 Umea, Sweden..
Show others and affiliations
2017 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 12, 19389-19402 p.Article in journal (Refereed) Published
Abstract [en]

Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.

Place, publisher, year, edition, pages
IMPACT JOURNALS LLC , 2017. Vol. 8, no 12, 19389-19402 p.
Keyword [en]
tongue cancer, RNA expression, field cancerization
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-319866DOI: 10.18632/oncotarget.14288ISI: 000396879200062OAI: oai:DiVA.org:uu-319866DiVA: diva2:1088636
Funder
Swedish Cancer Society, 15 06 37
Available from: 2017-04-13 Created: 2017-04-13 Last updated: 2017-04-13Bibliographically approved

Open Access in DiVA

fulltext(2336 kB)24 downloads
File information
File name FULLTEXT01.pdfFile size 2336 kBChecksum SHA-512
bf30ded06acba840e0066888ccd8384497a7aebdb58899cf44bf1cff710fcb69d4e587285a47f2a717787ebcbb611f0c9ba1ba5d69c99415b942f007f50db3f5
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Laurell, Göran
By organisation
Otolaryngology and Head and Neck Surgery
In the same journal
OncoTarget
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 24 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 166 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf