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Supernumerary human hair cells-signs of regeneration or impaired development?: A field emission scanning electron microscopy study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria.;Med Campus Univ Oldenburg Sch Med & Hlth Sci, European Med Sch, Oldenburg, Germany.;Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany.;Eberhard Karls Univ Tubingen, Tubingen Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, DE-72076 Tubingen, Germany..
Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria.;Med Campus Univ Oldenburg Sch Med & Hlth Sci, European Med Sch, Oldenburg, Germany.;Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany.;Eberhard Karls Univ Tubingen, Tubingen Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, DE-72076 Tubingen, Germany..
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2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 1, p. 11-19Article in journal (Refereed) Published
Abstract [en]

Background: Current attempts to regenerate cochlear sensorineural structures motivate further inspection of the human organ of hearing. Here, we analyzed the supernumerary inner hair cell (sIHC), a possible sign of regeneration and cell replacement. Methods: Human cochleae were studied using field emission scanning electron microscopy (FESEM; maximum resolution 2 nm) obtained from individuals aged 44, 48, and 58 years with normal sensorineural pure-tone average (PTA) thresholds (PTA < 20 dB). The wasted tissue was harvested during trans-cochlear approaches and immediately fixed for ultrastructural analysis. Results: All specimens exhibited sIHCs at all turns except at the extreme lower basal turn. In one specimen, it was possible to image and count the inner hair cells (IHCs) along the cochlea representing the 0.2 kHz-8 kHz region according to the Greenwood place/frequency scale. In a region with 2,321 IHCs, there were 120 scattered one-cell losses or 'gaps' (5%). Forty-two sIHCs were present facing the modiolus. Thirty-eight percent of the sIHCs were located near a 'gap' in the IHC row (+/- 6 IHCs). Conclusions: The prevalence of ectopic inner hair cells was higher than expected. The morphology and placement could reflect a certain ongoing regeneration. Further molecular studies are needed to verify if the regenerative capacity of the human auditory periphery might have been underestimated.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 122, no 1, p. 11-19
Keywords [en]
Human cochlea, inner hair cell, regeneration, SEM, supernumerary hair cells
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-319780DOI: 10.1080/03009734.2016.1271843ISI: 000396476600002PubMedID: 28145795OAI: oai:DiVA.org:uu-319780DiVA, id: diva2:1088279
Funder
EU, European Research Council, 603029Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-11-29Bibliographically approved

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