Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Eight-year follow-up of airway hyperresponsiveness in patients with primary Sjögren's syndrome
Univ Hosp, Dept Allergy, Reykjavik, Iceland.;Univ Hosp, Dept Resp Med, Reykjavik, Iceland..
Univ Hosp, Ctr Rheumatol Res, Reykjavik, Iceland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 1, 51-55 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate in a longitudinal study the influence of airway hyperresponsiveness (AHR) on lung function in patients with primary Sjogren's syndrome (pSS). Methods: Lung function was studied over an eight-year period in 15 patients who fulfilled the Copenhagen criteria for primary Sjogren's syndrome and who were covered in our earlier published study on AHR in patients with Sjogren's syndrome. Standard spirometry and measurements of lung volumes, diffusing capacity (DLCO), and AHR to methacholine were performed. Results: A significant decline over time was found in total lung capacity (TLC), vital capacity (VC), forced vital capacity (FVC), functional residual capacity (FRC), and expiratory midflows (FEF50). A sign of small airway obstruction (decrease in FEF50) at entry correlated with VC at follow-up (r = .8, P < .003), and the individual change in FEF50 during the observation period correlated with the individual change in VC (r = .6, P < .05). Six patients had increased AHR, and three of them had decreased DLCO. Six of the patients progressively reduced DLCO over time, and five of them had spirometric signs of increased small airway obstruction. Conclusions: During this eight-year follow-up we observed that one-third of the patients with pSS developed a significant reduction in lung function. Our findings suggest that small airways obstruction and AHR are associated with reduction of VC and development of impaired DLCO as a sign of interstitial lung disease in this group of patients.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 122, no 1, 51-55 p.
Keyword [en]
Airway hyperresponsiveness, follow-up, lung function, Sjogren's syndrome
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-319785DOI: 10.1080/03009734.2016.1239663ISI: 000396476600007PubMedID: 27849141OAI: oai:DiVA.org:uu-319785DiVA: diva2:1088270
Funder
Swedish Heart Lung Foundation
Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-04-12Bibliographically approved

Open Access in DiVA

fulltext(559 kB)21 downloads
File information
File name FULLTEXT01.pdfFile size 559 kBChecksum SHA-512
c9250191d96b7e131ae8000d9c00164a1b095a6debf715e3416b6b2d4c2d42f5ed86bb0c3a1258385d0ba3bcc2f13250780ef723f4574b690a9518a8892ce780
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hedenström, HansHällgren, Roger
By organisation
Clinical PhysiologyDepartment of Medical Sciences
In the same journal
Upsala Journal of Medical Sciences
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
Total: 21 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 171 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf