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Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Univ Örebro, Dept Pathol, Örebro, Sweden..
Falun Cent Hosp, Dept Pathol, Falun, Sweden..
Univ Helsinki, Cent Hosp, Dept Oncol, Helsinki, Finland..
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2017 (English)In: International Journal of Breast Cancer, ISSN 2090-3170, E-ISSN 2090-3189, article id 4351319Article in journal (Refereed) Published
Abstract [en]

Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabar. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER-and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 (0.13-1.08) and 0.82 (0.29-2.27), respectively, and the HR of an in situ IBE was 0.90 (0.41-1.95) and 1.60 (0.75-3.39), respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017. article id 4351319
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Cancer and Oncology
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URN: urn:nbn:se:uu:diva-319323DOI: 10.1155/2017/4351319ISI: 000394652400001OAI: oai:DiVA.org:uu-319323DiVA, id: diva2:1087867
Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-11-29Bibliographically approved

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