Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A review of sex-specific benefits and risks of antithrombotic therapy in acute coronary syndrome
Duke Univ, Med Ctr, Duke Clin Res Inst, Duke Box 3850,2400 Pratt St, Durham, NC 27705 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Duke Univ, Med Ctr, Duke Clin Res Inst, Duke Box 3850,2400 Pratt St, Durham, NC 27705 USA..
2017 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, no 3, p. 165-171Article in journal (Refereed) Published
Abstract [en]

Over the past decade, more men than women have shown improved outcomes from antithrombotic therapies after acute coronary syndrome (ACS), which raises the question of whether there are sex-specific differences in treatment patterns and response to therapy. Differences in presenting clinical characteristics, pathophysiologic profile, and disparities in treatment may contribute to this outcomes discrepancy. Analyses of large trials and registry data suggest that male and female ACS patients experience similar benefits from antithrombotic therapy without significant difference in treatment utilization rates, yet women are consistently at higher risk of bleeding than men. Bleeding may result in antithrombotic treatment disruption, which increases the risk of long-term thrombotic events. Additionally, female ACS patients are more likely to receive suboptimal medication dosing and have lower rates of long-term medication adherence. These differences have significant clinical implications for women, indicating the need for strategies that will optimize initial treatment and long-term management attuned to these recognized sex-specific gaps.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2017. Vol. 38, no 3, p. 165-171
Keywords [en]
Acute coronary syndrome, Antithrombotic therapy, Sex-specific differences
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-319665DOI: 10.1093/eurheartj/ehv758ISI: 000394009100013PubMedID: 28158545OAI: oai:DiVA.org:uu-319665DiVA, id: diva2:1087472
Funder
GlaxoSmithKline (GSK)Available from: 2017-04-07 Created: 2017-04-07 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

fulltext(229 kB)93 downloads
File information
File name FULLTEXT01.pdfFile size 229 kBChecksum SHA-512
4c130e76da0e9b268b5cd6f287a5f8b060b71634f9723a83d846ae548b9e5ef119ba2dd7a6874ff5b8de0f6bc85f6646ec583115b605fda802d9370e204afa6a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
James, Stefan K
By organisation
UCR-Uppsala Clinical Research Center
In the same journal
European Heart Journal
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 93 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 266 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf