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Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial
Karolinska Univ Hosp Huddinge, Stockholm CF Ctr, K56, S-14186 Stockholm, Sweden.;Karolinska Inst, Div Pediat, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden..
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2017 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 71, no 2, p. 203-205Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/OBJECTIVES: Vitamin D insufficiency in cystic fibrosis is common. Vitamin D3 is currently preferred over D2. We aimed to study the efficacy of vitamin D2 and D3 at increasing serum 25-hydroxyvitamin D (s25OHD) concentrations and their effect on respiratory health in cystic fibrosis. SUBJECTS/METHODS: Sixteen CF patients were randomized to receive vitamin D2 or D3 or to serve as controls. The starting dose of 5000 IU (< 16 years old) or 7143 IU/day (>= 16 years old) was further individually adjusted. Three months of intervention were followed by two of washout (ClinicalTrials. gov NCT01321905). RESULTS: To increase s25OHD, the mean daily dose of vitamin D2 and D3 had to be increased up to 15650 and 8184 IU, respectively. The combined group of vitamin D2 and D3 treated patients decreased plasma IL-8 (P < 0.05). Patients provided vitamin D3 improved FVC at the end of the trial (P < 0.05). Change in s25OHD was positively correlated with changes in the adult Quality-of-Life respiratory score at the end of supplementation (P = 0.006, r = 0.90), and with changes in FEV1 (P = 0.042, r = 0.62) and FVC (P = 0.036, r = 0.63) at one month of washout. CONCLUSIONS: Vitamin D supplementation may contribute to reduced inflammation and improved lung function in CF.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 71, no 2, p. 203-205
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Nutrition and Dietetics
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URN: urn:nbn:se:uu:diva-319573DOI: 10.1038/ejcn.2016.259ISI: 000394027500010PubMedID: 27966575OAI: oai:DiVA.org:uu-319573DiVA, id: diva2:1087168
Funder
The Karolinska Institutet's Research FoundationStockholm County CouncilSwedish Research CouncilSwedish Heart Lung FoundationSwedish Cancer SocietyAvailable from: 2017-04-06 Created: 2017-04-06 Last updated: 2017-11-29Bibliographically approved

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