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The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
Univ Orebro, Sch Med Sci, Dept Med, Orebro, Sweden..
Univ Orebro, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.;Karolinska Inst, Karolinska Univ Hosp, Clin Epidemiol Unit, Stockholm, Sweden.;UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England..
Univ Orebro, Sch Med Sci, Dept Transfus Med, Orebro, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2017 (English)In: Journal of Blood Medicine, ISSN 1179-2736, Vol. 8, p. 29-34Article in journal (Refereed) Published
Abstract [en]

Background: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10-15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM). Methods: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD. Results: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively). Conclusion: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD.

Place, publisher, year, edition, pages
DOVE MEDICAL PRESS LTD , 2017. Vol. 8, p. 29-34
Keywords [en]
plasma cells, neoplasms, amyloidosis, renal insufficiency, proteinuria
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-319324DOI: 10.2147/JBM.S129516ISI: 000395472700001PubMedID: 28293126OAI: oai:DiVA.org:uu-319324DiVA, id: diva2:1086676
Available from: 2017-04-03 Created: 2017-04-03 Last updated: 2017-11-29Bibliographically approved

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