Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evidence for cognitive resource imbalance in adolescents with narcolepsy
Linkoping Univ US, Ctr Med Image Sci & Visualizat CMIV, Linkoping Univ, SE-58185 Linkoping, Sweden.
Linkoping Univ US, Ctr Med Image Sci & Visualizat CMIV, Linkoping Univ, SE-58185 Linkoping, Sweden.; Linkoping Univ, Dept Med & Hlth Sci IMH, Linkoping, Sweden.
Linkoping Univ US, Ctr Med Image Sci & Visualizat CMIV, Linkoping Univ, SE-58185 Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, Radiat Phys, Linkoping, Sweden.
Linkoping Univ, Linnaeus Ctr HEAD, Linkoping, Sweden.
Show others and affiliations
2018 (English)In: Brain Imaging and Behavior, ISSN 1931-7557, E-ISSN 1931-7565, Vol. 12, no 2, p. 411-424Article in journal (Refereed) Published
Abstract [en]

The study investigated brain activity changes during performance of a verbal working memory task in a population of adolescents with narcolepsy. Seventeen narcolepsy patients and twenty healthy controls performed a verbal working memory task during simultaneous fMRI and EEG acquisition. All subjects also underwent MRS to measure GABA and Glutamate concentrations in the medial prefrontal cortex. Activation levels in the default mode network and left middle frontal gyrus were examined to investigate whether narcolepsy is characterized by an imbalance in cognitive resources. Significantly increased deactivation within the default mode network during task performance was observed for the narcolepsy patients for both the encoding and recognition phases of the task. No evidence for task performance deficits or reduced activation within the left middle frontal gyrus was noted for the narcolepsy patients. Correlation analyses between the spectroscopy and fMRI data indicated that deactivation of the anterior aspect of the default mode in narcolepsy patients correlated more with increased concentrations of Glutamate and decreased concentrations of GABA. In contrast, deactivation in the default mode was correlated with increased concentrations of GABA and decreased concentrations of Glutamate in controls. The results suggested that narcolepsy is not characterized by a deficit in working memory but rather an imbalance of cognitive resources in favor of monitoring and maintaining attention over actual task performance. This points towards dysregulation within the sustained attention system being the origin behind self-reported cognitive difficulties in narcolepsy.

Place, publisher, year, edition, pages
2018. Vol. 12, no 2, p. 411-424
Keywords [en]
EEG, GABA, MRS, Narcolepsy, Working memory, fMRI
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-318746DOI: 10.1007/s11682-017-9706-yISI: 000429029000011PubMedID: 28321606OAI: oai:DiVA.org:uu-318746DiVA, id: diva2:1085198
Funder
Knut and Alice Wallenberg FoundationMedical Research Council of Southeast Sweden (FORSS)Available from: 2017-03-28 Created: 2017-03-28 Last updated: 2018-06-13Bibliographically approved

Open Access in DiVA

fulltext(1088 kB)3 downloads
File information
File name FULLTEXT01.pdfFile size 1088 kBChecksum SHA-512
50cb8bc1f129228a4afe31e0639f27b8e9a205ff1b8aff832ba924463602e4013b35efabc0a9f258f81f82acce23c9af6ec614f6327095eaa14bd63220962f3e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Landtblom, Anne-Marie
By organisation
Neurology
In the same journal
Brain Imaging and Behavior
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 3 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 336 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf