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Texture Analysis and Synthesis of Malignant and Benign Mediastinal Lymph Nodes in Patients with Lung Cancer on Computed Tomography
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-4255-5130
Fukushima Medical University, Japan.
Fukushima Medical University, Japan.
Fukushima Medical University, Japan.
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 43209Article in journal (Refereed) Published
Abstract [en]

Texture analysis of computed tomography (CT) imaging has been found useful to distinguish subtle differences, which are in-visible to human eyes, between malignant and benign tissues in cancer patients. This study implemented two complementary methods of texture analysis, known as the gray-level co-occurrence matrix (GLCM) and the experimental semivariogram (SV) with an aim to improve the predictive value of evaluating mediastinal lymph nodes in lung cancer. The GLCM was explored with the use of a rich set of its derived features, whereas the SV feature was extracted on real and synthesized CT samples of benign and malignant lymph nodes. A distinct advantage of the computer methodology presented herein is the alleviation of the need for an automated precise segmentation of the lymph nodes. Using the logistic regression model, a sensitivity of 75%, specificity of 90%, and area under curve of 0.89 were obtained in the test population. A tenfold cross-validation of 70% accuracy of classifying between benign and malignant lymph nodes was obtained using the support vector machines as a pattern classifier. These results are higher than those recently reported in literature with similar studies.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 7, article id 43209
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:liu:diva-136059DOI: 10.1038/srep43209ISI: 000395174200001PubMedID: 28233795OAI: oai:DiVA.org:liu-136059DiVA, id: diva2:1084830
Available from: 2017-03-27 Created: 2017-03-27 Last updated: 2017-11-29

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