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Prediction of treatment response in Social Anxiety Disorder, what does the brain tell us that questionnaires do not?: Using brain activity related to self- and other-referential criticism to predict treatment response to Internet- delivered Cognitive Behaviour Therapy for Social Anxiety Disorder
Linköping University, Department of Behavioural Sciences and Learning.
Linköping University, Department of Behavioural Sciences and Learning.
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Predicting who will benefit from what in the treatment of psychiatric disorders is incremental to future development of psychological treatments. In the current study functional magnetic resonance imaging (fMRI) data from participants with social anxiety disorder (SAD) was used to elucidate whether neural responses to negative evaluation could predict treatment response in SAD. Nine weeks prior to Internet- delivered Cognitive Behaviour Therapy (ICBT) onset, participants viewed negative social stimuli directed either at themselves or an significant other during fMRI scanning. Regression analyses including the differential activations for other-referential criticism in contrast to self-referential criticism in the posterior mid cingulate cortex (pMCC) and the lingual gyrus (LG) predicted 34% of treatment change as measured by residual gain scores on the Liebowitz Social Anxiety Scale Self-Report (LSAS-SR) in our sample. The final regression model, combining these measures with behavioural measures, which by themselves explained 27% of the variance, resulted in a model explaining 50% of the variance regarding treatment response. This lends additional support to the notion that further elucidating the neurobiological underpinnings of core processes in SAD, as well as the neural correlates of treatment response to CBT, would be of great value in predicting treatment outcome. 

Place, publisher, year, edition, pages
2016. , p. 65
Keyword [en]
Social Anxiety Disorder, Prediction, Neuroimaging, Functional Magnetic Resonance Imaging, Cingulate cortex, Lingual Gyrus, Internet-delivered Cognitive Behaviour Therapy.
National Category
Neurosciences Psychology
Identifiers
URN: urn:nbn:se:liu:diva-135740ISRN: LIU-IBL/PY-D—16/422—SEOAI: oai:DiVA.org:liu-135740DiVA, id: diva2:1083060
Subject / course
Master Thesis in Psychologist Programme
Presentation
2016-05-26, KY31, Key, Linköpings University 581 83, Linköping, 16:24 (Swedish)
Supervisors
Examiners
Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2018-01-13Bibliographically approved

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CiteExportLink to record
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