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Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study
Karolinska Inst, Dept Med Epidemiol & Biostat, MEB, Box 281, S-17177 Stockholm, Sweden.;Med Univ Warsaw, Dept Child Psychiat, Warsaw, Poland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Karolinska Inst, Dept Med Epidemiol & Biostat, MEB, Box 281, S-17177 Stockholm, Sweden.
Karolinska Inst, Dept Med Epidemiol & Biostat, MEB, Box 281, S-17177 Stockholm, Sweden.;Univ Orebro, Dept Med Sci, Orebro, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, Molndal, Sweden.;Univ Gothenburg, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden..
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2017 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432, Vol. 47, no 1, p. 80-89Article in journal (Refereed) Published
Abstract [en]

Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973-2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability.

Place, publisher, year, edition, pages
2017. Vol. 47, no 1, p. 80-89
Keyword [en]
Autism spectrum disorder, Addiction, ADHD, Intellectual disability, ICD
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-317673DOI: 10.1007/s10803-016-2914-2ISI: 000392816700007PubMedID: 27734228OAI: oai:DiVA.org:uu-317673DiVA, id: diva2:1082400
Funder
Swedish Research Council, 340-2013-5867Forte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2017-03-16 Created: 2017-03-16 Last updated: 2017-11-29Bibliographically approved

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Långström, Niklas
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Child and Adolescent PsychiatryDepartment of Neuroscience
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