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The molecular basis of endothelial cell plasticity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. FIRC Inst Mol Oncol, Vasc Biol Unit, I-20129 Milan, Italy..
Yale Cardiovasc Res Ctr, Dept Internal Med, New Haven, CT 06511 USA.;Yale Cardiovasc Res Ctr, Dept Genet, New Haven, CT 06511 USA.;Yale Cardiovasc Res Ctr, Dept Biomed Engn, New Haven, CT 06511 USA..
Yale Univ, Sch Med, Yale Cardiovasc Res Ctr, Dept Internal Med, 333 Cedar St, New Haven, CT 06511 USA.;Yale Univ, Sch Med, Dept Cell Biol, 333 Cedar St, New Haven, CT 06511 USA..ORCID iD: 0000-0003-0348-7734
2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 14361Article, review/survey (Refereed) Published
Abstract [en]

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions.

Place, publisher, year, edition, pages
2017. Vol. 8, article id 14361
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-317094DOI: 10.1038/ncomms14361ISI: 000393587100001PubMedID: 28181491OAI: oai:DiVA.org:uu-317094DiVA, id: diva2:1080541
Funder
EU, European Research Council, 268870 317250 675619NIH (National Institute of Health), HL053793 P01 HL107205 HL128064 HL096360 EB017103Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-11-29Bibliographically approved

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