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Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab. Stockholm Univ, Dept Biophys & Biochem, Sci Life Lab, Box 1031, SE-17121 Solna, Sweden..
Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA..
Stockholm Univ, Dept Biophys & Biochem, Sci Life Lab, Box 1031, SE-17121 Solna, Sweden..
Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA..
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2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 13913Article in journal (Refereed) Published
Abstract [en]

Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samples can be imaged and analysed using mobile phone microscopy, achieving a new milestone for tele-medicine technologies.

Place, publisher, year, edition, pages
2017. Vol. 8, article id 13913
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-315810DOI: 10.1038/ncomms13913ISI: 000391931300001PubMedID: 28094784OAI: oai:DiVA.org:uu-315810DiVA: diva2:1076170
Funder
Swedish Research CouncilSwedish Cancer Society, 2015/838 2015/629Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Available from: 2017-02-22 Created: 2017-02-22 Last updated: 2017-11-29Bibliographically approved

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Kühnemund, MalteMathot, LucySjöblom, TobiasNilsson, Mats
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