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Catestatin and vasostatin concentrations in healthy dogs
Swedish Univ Agr Sci, Dept Clin Sci, Box 7504, S-75007 Uppsala, Sweden.;Khon Kaen Univ, Fac Vet Med, Dept Surg & Theriogenol, Khon Kaen 40002, Thailand..
Swedish Univ Agr Sci, Dept Clin Sci, Box 7504, S-75007 Uppsala, Sweden..
Swedish Univ Agr Sci, Dept Clin Sci, Box 7504, S-75007 Uppsala, Sweden..
Swedish Univ Agr Sci, Unit Appl Stat & Math, Box 7032, S-75007 Uppsala, Sweden..
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2017 (English)In: ACTA VETERINARIA SCANDINAVICA, ISSN 0044-605X, Vol. 59, article id 1Article in journal (Refereed) Published
Abstract [en]

Background: The neuroendocrine glycoprotein chromogranin A is a useful biomarker in humans for neuroendocrine tumors and stress. Chromogranin A can be measured in both blood and saliva. The objective of this study was to investigate concentrations of and correlation between the chromogranin A epitopes catestatin and vasostatin in healthy dogs accustomed to the sample collection procedures. Blood and saliva samples were collected from 10 research Beagle dogs twice daily for 5 consecutive days, and from 33 privately-owned blood donor dogs in association with 50 different blood donation occasions. All dogs were familiar with sample collection procedures. During each sampling, stress behavior was scored by the same observer using a visual analog scale (VAS) and serum cortisol concentrations. Catestatin and vasostatin were analyzed using radioimmunoassays for dogs. Results: The dogs showed minimal stress behavior during both saliva sampling and blood sampling as monitored by VAS scores and serum cortisol concentrations. Few and insufficient saliva volumes were obtained and therefore only catestatin could be analyzed. Catestatin concentrations differed significantly and did not correlate significantly with vasostatin concentrations (P < 0.0001). Age, gender, breed, and time of sample collection did not significantly affect concentrations of plasma catestatin, vasostatin, and saliva catestatin. Conclusions: The normal ranges of plasma catestatin (0.53-0.98 nmol/l), vasostatin (0.11-1.30 nmol/l), and saliva catestatin (0.31-1.03 nmol/l) concentrations in healthy dogs accustomed to the sampling procedures were determined. Separate interpretation of the different chromogranin A epitopes from either saliva or plasma is recommended.

Place, publisher, year, edition, pages
2017. Vol. 59, article id 1
Keyword [en]
Catestatin, Chromogranin A, Healthy dogs, Stress behavior visual analog scale, Vasostatin
National Category
Veterinary Science
Identifiers
URN: urn:nbn:se:uu:diva-315824DOI: 10.1186/s13028-016-0274-8ISI: 000391892700001PubMedID: 28049540OAI: oai:DiVA.org:uu-315824DiVA, id: diva2:1076026
Available from: 2017-02-21 Created: 2017-02-21 Last updated: 2017-02-21Bibliographically approved

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