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Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. (Centre for Personalized Medicine)
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-1239-5495
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
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2016 (English)In: Journal of Immunology Research, ISSN 2314-8861, E-ISSN 2314-7156, 5153184Article in journal (Refereed) Published
Abstract [en]

Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive Tcells into Th1 cells. As SIT is thought to cause a shift towardsTh1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4(+) T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.

Place, publisher, year, edition, pages
HINDAWI PUBLISHING CORP , 2016. 5153184
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Other Clinical Medicine
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URN: urn:nbn:se:liu:diva-134628DOI: 10.1155/2016/5153184ISI: 000392607400001PubMedID: 28097155OAI: oai:DiVA.org:liu-134628DiVA: diva2:1075701
Note

Funding Agencies|Swedish Research Council [2015-02575]

Available from: 2017-02-20 Created: 2017-02-20 Last updated: 2017-11-29

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Mattson, LinaLentini, AntonioGawel, DanutaBadam, TejaswiBenson, MikaelLedin, TorbjörnNestor, ColmGustafsson, MikaSerra I Musach, JordiZhang, Huan
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Division of Clinical SciencesFaculty of Medicine and Health SciencesBioinformaticsFaculty of Science & EngineeringAllergy CenterDivision of Neuro and Inflammation ScienceDepartment of Otorhinolaryngology in Linköping
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