Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hospital Recorded Morbidity and Breast Cancer Incidence: A Nationwide Population-Based Case-Control Study
Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark..
Aarhus Univ Hosp, Aalborg Hosp, Breast Clin, DK-8000 Aarhus, Denmark..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology. Aarhus Univ Hosp, Aalborg Hosp, Dept Oncol, DK-8000 Aarhus, Denmark..
Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark..
Show others and affiliations
2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 10, article id e47329Article in journal (Refereed) Published
Abstract [en]

Introduction: Chronic diseases and their complications may increase breast cancer risk through known or still unknown mechanisms, or by shared causes. The association between morbidities and breast cancer risk has not been studied in depth. Methods: Data on all Danish women aged 45 to 85 years, diagnosed with breast cancer between 1994 and 2008 and data on preceding morbidities were retrieved from nationwide medical registries. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression associating the Charlson comorbidity score (measured using both the original and an updated Charlson Comorbidity Index (CCI)) with incident breast cancer. Furthermore, we estimated associations between 202 morbidity categories and incident breast cancer, adjusting for multiple comparisons using empirical Bayes (EB) methods. Results: The study included 46,324 cases and 463,240 population controls. Increasing CCI score, up to a score of six, was associated with slightly increased breast cancer risk. Among the Charlson diseases, preceding moderate to severe renal disease (OR = 1.25, 95% CI: 1.06, 1.48), any tumor (OR = 1.17, 95% CI: 1.10, 1.25), moderate to severe liver disease (OR = 1.86, 95% CI: 1.32, 2.62), and metastatic solid tumors (OR = 1.49, 95% CI: 1.17, 1.89), were most strongly associated with subsequent breast cancer. Preceding myocardial infarction (OR = 0.89, 95% CI: 0.81, 0.99), connective tissue disease (OR = 0.87, 95% CI: 0.80, 0.94), and ulcer disease (OR = 0.91, 95% CI: 0.83, 0.99) were most strongly inversely associated with subsequent breast cancer. A history of breast disorders was associated with breast cancer after EB adjustment. Anemias were inversely associated with breast cancer, but the association was near null after EB adjustment. Conclusions: There was no substantial association between morbidity measured with the CCI and breast cancer risk.

Place, publisher, year, edition, pages
2012. Vol. 7, no 10, article id e47329
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-315527DOI: 10.1371/journal.pone.0047329ISI: 000310050200021PubMedID: 23094045OAI: oai:DiVA.org:uu-315527DiVA, id: diva2:1074571
Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

fulltext(127 kB)19 downloads
File information
File name FULLTEXT01.pdfFile size 127 kBChecksum SHA-512
f59a1322604843be3dda6a536399adebb42ef9f542038d6083eb7a95bd992e5640cf4894527ab80e5ac178ebbdfbfd1500de3e8ba76c02f1f7e3a3d01cdfece2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nyström, Petra Mariann Witt
By organisation
Oncology
In the same journal
PLoS ONE
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 19 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 356 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf